34941-91-8

Basic information

• Product Name: 2-Chloro-4-fluoropyridine
• Synonyms: 2-CHLORO-4-FLUOROPYRIDINE;2-Chloro-4-fluoropyridine,97%;2-CHLORO-4-FULOROPYRIDINE;2-Chlro-4-fluorpyridine;2--4- fluoropyridinechloride;2-Chloro-4-fluoropyridine AldrichCPR
• CAS NO: 34941-91-8
• Molecular Formula: C₅H₃ClFN
• Molecular Weight: 131.54
• EINECS: -0
• Product Categories: Fluorin-contained pyridine series;Halides;Pyridines;Pyridine;Variety of halogenated heterocyclic series;Building Blocks;C5;Chemical Synthesis;Heterocyclic Building Blocks;New Products for Chemical Synthesis;Fluorine series
• Mol File: 34941-91-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 140°C
• Flash Point: 140°C
• Appearance: Colorless to pale yellow/Liquid
• Density: 1,456g/cm
• Vapor Pressure: 3.49mmHg at 25°C
• Refractive Index: 1.5015
• Storage Temp.: Room temperature.
• PKA: 1.20±0.10(Predicted)
• BRN: 1634747
• CAS DataBase Reference: 2-Chloro-4-fluoropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-4-fluoropyridine(34941-91-8)
• EPA Substance Registry System: 2-Chloro-4-fluoropyridine(34941-91-8)

Safety Data

• Hazard Codes: Xi,F,Xn
• Statements: 20/21/22-36/37/38-10
• Safety Statements: 26-36/37/39-36
• RIDADR: 1993
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 34941-91-8(Hazardous Substances Data)

Usage

Chemical Properties

Colorless liquid

Uses

2-Chloro-4-fluoropyridine is a useful research chemical.

InChI:InChI=1/C5H3ClFN/c6-5-3-4(7)1-2-8-5/h1-3H

Upstream product

• 23056-36-2 2-chloro-4-nitropyridine 

Downstream Products

• 953765-04-3 (1R,2R)-2-(6-(2-chloropyridin-4-yloxy)benzo[d]thiazol-2-ylamino)cyclohexanol 
• 935265-48-8 2-(1-(tert-butyldimethylsilyloxy)-7-phenylheptyl)-5-(4-fluoropyridin-2-yl)oxazole 
• 936343-13-4 4-(4-fluoro-pyridin-2-yloxymethyl)-benzonitrile 
• 1237535-76-0 4-fluoropyridin-2-ylcarbamic acid tert-butyl ester 
• 1235313-80-0 N-(4-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-5-methylthiazol-2-yl)-4-fluoropyridin-2-amine 
• 1117685-78-5 4-fluoro-N-(3,4,5-trimethoxyphenyl)pyridin-2-amine 
• 1051315-32-2 2-(2-(2-chloropyridin-4-ylamino)ethyl)-6-phenylpyridazin-3(2H)-one 
• 1051315-33-3 2-(2-(2-chloropyridin-4-yloxy)ethyl)-6-phenylpyridazin-3(2H)-one 

Relevant articles and documents

Tetrabutylammonium salt induced denitration of nitropyridines: Synthesis of fluoro-, hydroxy-, and methoxypyridines

(Chemical Equation Presented) An efficient method for the synthesis of fluoropyridines via the fluorodenitration reaction is reported. The reaction is mediated by tetrabutylammonium fluoride (TBAF) under mild conditions without undue regard to the presence of water. The fluorodenitration is general for 2- or 4-nitro-substituted pyridines, while 3-nitropyridines require attendant electron-withdrawing groups for the reaction to proceed efficiently. Nitropyridines also undergo hydroxy- and methoxydenitration under mild conditions in the presence of the corresponding tetrabutylammonium species.