35034-15-2Relevant articles and documents
AN IMPROVED PROCEDURE FOR THE PREPARATION OF AROMATIC HETEROCYCLIC N-OXIDES
Rhie, Soo Young,Ryu, Eung K.
, p. 323 - 328 (2007/10/03)
An improved procedure for the preparation of aromatic heterocyclic N-oxide is described.Nitrogen containing heterocyclic compounds gave their N-oxides in excellent yields by the reaction of m-CPBA in DMF/MeOH in the presence of HF in a short time under mild reaction conditions.The presence of HF and MeOH is crucial for the reaction.
Synthesis of some pyrimidine N-oxides
Jovanovic, Misa V.
, p. 1176 - 1180 (2007/10/02)
Various monosubstitudes pyrimidines and methylpyrimidines were N-oxidized with a number of different peracids.In general, they are more susceptible to side reactions accompanying N-oxidation (i.e., decomposition, annular carbon oxidation, ring opening) than other ?-deficient diazine and triazine analogs.Unsymmetrical pyrimidines, which can potentially yield two isomeric products, were N-oxidized preferentially at the site para to strong electron-donating substituents.Weaker ringactivating groups, such as methyl, are mainly ortho directing and only aid in the N-oxidation of pyrimidine nuclei having ortho/para-directing substituents.