350592-84-6

Basic information

• Product Name: (2S,3S)- 3-hydroxy-2-PyrrolidineMethanol
• Synonyms: (2S,3S)- 3-hydroxy-2-PyrrolidineMethanol;2-Pyrrolidinemethanol, 3-hydroxy-, hydrochloride (1:1), (2S,3S)-
• CAS NO: 350592-84-6
• Molecular Formula: C5H11NO2
• Molecular Weight: 117.14634
• EINECS: -0
• Mol File: 350592-84-6.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2S,3S)- 3-hydroxy-2-PyrrolidineMethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3S)- 3-hydroxy-2-PyrrolidineMethanol(350592-84-6)
• EPA Substance Registry System: (2S,3S)- 3-hydroxy-2-PyrrolidineMethanol(350592-84-6)

Safety Data

• Hazardous Substances Data: 350592-84-6(Hazardous Substances Data)

Usage

General Description

The chemical compound (2S,3S)-3-hydroxy-2-PyrrolidineMethanol is a derivative of the amino acid proline and is classified as a chiral compound due to its asymmetric carbon centers. It has a pyrrolidine ring structure with a hydroxyl group attached at the 3rd position and a methanol group at the 2nd position. (2S,3S)- 3-hydroxy-2-PyrrolidineMethanol is commonly used in organic synthesis and pharmaceutical research as a building block for the synthesis of various bioactive molecules. Its stereochemical configuration and functional groups make it suitable for the development of drugs targeting specific biological processes or receptors, making it a valuable tool in medicinal chemistry.

Upstream product

• 123098-96-4 (2R,3R)-2-Hydroxymethyl-1-((S)-1-phenyl-ethyl)-pyrrolidin-3-ol 
• 123076-45-9 trans-N-benzyl-3-hydroxy-2-<(triphenylmethoxy)methyl>pyrrolidine 
• 350592-88-0 (S,R)-3-acetoxy-2-hydroxymethylpyrrolidine benzoate 
• 350592-77-7 (S,R)-4-hydroxy-4-(4,5-dihydro-2-phenyl-4-oxazolyl)-1-butene 
• 350592-76-6 (S,S)-4-hydroxy-4-(4,5-dihydro-2-phenyl-4-oxazolyl)-1-butene 
• 350592-83-5 (S,S)-3-acetoxy-2-hydroxymethylpyrrolidine benzoate 
• 350592-78-8 (R,S)-4-hydroxy-4-(4,5-dihydro-2-phenyl-4-oxazolyl)-1-butene 
• 350592-92-6 (R,S)-3-acetoxy-2-hydroxymethylpyrrolidine benzoate 
• 123076-22-2 N-benzyl-3-hydroxypent-4-enethioamide 
• 123076-60-8 (4R,5S)-N-<(S)-1-phenylethyl>-4-hydroxy-5-(iodomethyl)pyrrolidin-2-one 

Relevant articles and documents

Anin vitro-in vivosequential cascade for the synthesis of iminosugars from aldoses

Here, we report a chemoenzymatic approach for the preparation of a small panel of biologically important iminosugars from readily available aldoses. Our approach involves anin vitrotransaminase-mediated amination of aldoses in combination with anin vivose

Highly regioselective oxirane ring-opening of a versatile epoxypyrrolidine precursor of new imino-sugar-based sphingolipid mimics

An in-depth study of the oxirane ring-opening reaction of a pivotal epoxypyrrolidine is reported. The introduction of various carbon- and heteroatom-centered nucleophiles at C4 has been achieved with high regiocontrol. The structures of the major products were assigned on the basis on an X-ray crystallographic study of six examples. A mechanistic study carried out at the B3LYP/6-31G** level of theory suggested that the steric control of the vinyl substituent was responsible for the regioselectivity. Finally, this approach was used to design and prepare imino-sugar-based sphingolipid mimics. A highly cytotoxic C-octylpyrrolidine is described. This compound was shown to interfere with the metabolism of sphing-olipids in murine melanoma cells, notably in inhibiting the production of glucosylceramide. Wiley-VCH Verlag GmbH & Co. KGaA.

C-Alkyl 5-membered ring imino sugars as new potent cytotoxic glucosylceramide synthase inhibitors

The stereoselective preparation of C-alkyl 5-membered ring imino sugars, their biological evaluation with regard to glucosyleramide synthase (GCS) inhibition, and cytotoxicity in a murine melanoma B16 cell model, were investigated. It was found that epoxy