350597-49-8 Usage
General Description
5-CHLORO-2-METHYL-NICOTINIC ACID METHYL ESTER is a chemical compound with the molecular formula C8H8ClNO2. It is a methyl ester derivative of 5-chloro-2-methyl-nicotinic acid, which is commonly used in the pharmaceutical industry as a building block for the synthesis of various drugs and biologically active compounds. 5-CHLORO-2-METHYL-NICOTINIC ACID METHYL ESTER is a chlorinated derivative of nicotinic acid, a precursor to the coenzymes NAD and NADP, and it has potential applications in the treatment of various diseases such as cancer, inflammation, and neurodegenerative disorders. The chemical and physical properties of 5-CHLORO-2-METHYL-NICOTINIC ACID METHYL ESTER make it a valuable intermediate for the development of new pharmaceuticals and agrochemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 350597-49-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,5,0,5,9 and 7 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 350597-49:
(8*3)+(7*5)+(6*0)+(5*5)+(4*9)+(3*7)+(2*4)+(1*9)=158
158 % 10 = 8
So 350597-49-8 is a valid CAS Registry Number.
InChI:InChI=1/C8H8ClNO2/c1-5-7(8(11)12-2)3-6(9)4-10-5/h3-4H,1-2H3
350597-49-8Relevant articles and documents
Process development and large-scale synthesis of a c-Met kinase inhibitor
Stewart, Gavin W.,Brands, Karel M. J.,Brewer, Sarah E.,Cowden, Cameron J.,Davies, Antony J.,Edwards, John S.,Gibson, Andrew W.,Hamilton, Simon E.,Katz, Jason D.,Keen, Stephen P.,Mullens, Peter R.,Scott, Jeremy P.,Wallace, Debra J.,Wise, Christopher S.
experimental part, p. 849 - 858 (2011/03/20)
A highly convergent synthesis of c-Met kinase inhibitor 1 has been demonstrated on a multikilogram scale using three key fragments: dihalotricyclic core 2, chiral sulfamide side chain 3, and pyrazole boronic ester 4. The chirality in sulfamide side chain 3 was installed using the cheap and readily available starting material (S)-epichlorohydrin. A total of 2.71 kg of 1 were isolated in seven steps (the longest linear sequence).
5H-BENZO[4,5]CYCLOHEPTA[1,2-B]PYRIDINE NMDA/NR2B ANTAGONISTS
-
Page/Page column 41-43, (2010/02/07)
Benzo [4,5]cyclohepta[1,2-b]pyridines represented by Formula (I): or pharmaceutically acceptable salts thereof, are effective as NMDA NR2B antagonists useful for relieving pain.