350797-51-2

Basic information

• Product Name: 1-(3-benzoyloxypropyl) Indoline hydrochloride
• Synonyms: 3-(indolin-1-yl)propyl benzoate hydrochloride; 1-(3-benzoyloxypropyl)indoline hydrochloride; 1-(3-benzoyloxypropyl)-2,3-dihydroindole hydrochloride
• CAS NO: 350797-51-2
• Molecular Formula: C₁₈H₁₉NO₂*ClH
• Molecular Weight: 317.81000
• Mol File: 350797-51-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-(3-benzoyloxypropyl) Indoline hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-benzoyloxypropyl) Indoline hydrochloride(350797-51-2)
• EPA Substance Registry System: 1-(3-benzoyloxypropyl) Indoline hydrochloride(350797-51-2)

Safety Data

• Hazardous Substances Data: 350797-51-2(Hazardous Substances Data)

Usage

General Description

1-(3-benzoyloxypropyl) Indoline hydrochloride is a chemical compound that is commonly used in pharmaceutical research and development. It is an indoline derivative, with a molecular structure consisting of a benzoyloxypropyl group attached to the nitrogen atom of the indoline ring. The hydrochloride salt form of the compound is often used to increase its solubility in aqueous solutions, making it easier to work with in a laboratory setting. This chemical may have potential applications in the development of new drugs for various medical conditions, and its unique properties make it a valuable tool for scientists and researchers in the pharmaceutical industry.

Upstream product

• 65-85-0 benzoic acid 
• 496-15-1 1-indoline 
• 942-95-0 3-chloropropyl benzoate 
• 109-70-6 1.3-chlorobromopropane 

Downstream Products

• 350797-52-3 1-(3-benzoyloxypropyl)-5-formyl-2,3-dihydroindole 
• 160970-54-7 silodosin 
• 239463-72-0 5-[(2R)-2-aminopropyl]-2,3-dihydro-1-[3-(benzoyloxy)propyl]-1H-indole-7-carbonitrile 
• 885340-11-4 2,3-dihydro-1-[3-(benzoyloxy)propyl]-5-[(2R)-2-[[2-[(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-1H-indole-7-carbonitrile 
• 885340-13-6 1-(3-hydroxypropyl)-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}amino)propyl]-2,3-dihydro-1H-indole-7-carbonitrile 
• 350797-53-4 1-(3-benzoyloxypropyl)-5-(2-nitro-1-propenyl)-2,3-dihydroindole 
• 350797-54-5 1-(3-benzoyloxypropyl)-5-(2-nitropropyl)-2,3-dihydroindole 
• 350797-55-6 1-(3-benzoyloxypropyl)-7-formyl-5-(2-nitropropyl)-2,3-dihydroindole 
• 350797-56-7 1-(3-benzoyloxypropyl)-7-cyano-5-(2-nitropropyl)-2,3-dihydroindole 
• 1338365-54-0 5-(2-aminopropyl)-1-[3-(benzoyloxy)propyl]-2,3-dihydro-7-cyano-1H-indole 
• 239463-85-5 5-[(2R)-2-aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indol-7-carbonitrile (2R,3R)-2,3-dihydroxybutanedioate salt 

Relevant articles and documents

METHOD FOR PREPARING SILODOSIN

The present invention relates to a process for preparing silodosin with high optical purity up to 99.9% enantiomeric excess (e.e.) or above. The process makes use of a method step, in which the enantiomers contained in a racemic mixture of a compound represented by the general formula V: wherein * denotes the asymmetric center, R1 is a protecting group, and R2 is cyano or carbamoyl, are separated.

PROCESS FOR PREPARING AN INTERMEDIATE FOR SILODOSIN

The present invention provides a process for preparing a compound of formula (I), wherein R1 is a hydroxyl-protecting group and R2 is a cyano group or a carbamoyl group, wherein the process comprises the direct hydrogenation of the corresponding achiral nitro compound and the resolution of the racemic amino compound. The compound of formula (I) can easily be further transferred to silodosin.