350797-55-6 Usage
Molecular structure
The compound consists of a benzoyloxypropyl group, a nitropropyl group, and an indole-7-carboxaldehyde group, connected through a dihydro-2,3 ring and a 1H-indole ring.
Functional groups
The compound contains several functional groups, including a benzoyloxy group, a nitro group, a propyl group, and a carboxylic aldehyde group.
Molecular weight
The molecular weight of the compound is approximately 407.42 g/mol.
Potential applications
The compound may have potential applications in pharmaceuticals, organic chemistry, or materials science due to its unique properties and reactivity.
Synthetic compound
It is likely a synthetic compound, which means it is created through a series of chemical reactions in a laboratory.
Reactivity
The compound may exhibit unique reactivity due to the combination of its functional groups and ring structures, making it of interest to researchers and chemical engineers.
Research interest
The compound's complex structure and potential applications make it a subject of interest for further study and exploration in the fields of chemistry and related disciplines.
Solubility
The solubility of the compound in various solvents is not explicitly mentioned, but it may be influenced by the presence of polar and nonpolar functional groups.
Stability
The stability of the compound under different conditions (e.g., temperature, pH, etc.) is not provided, but it may be affected by the presence of reactive functional groups such as the nitro group and the carboxylic aldehyde group.
Check Digit Verification of cas no
The CAS Registry Mumber 350797-55-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,5,0,7,9 and 7 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 350797-55:
(8*3)+(7*5)+(6*0)+(5*7)+(4*9)+(3*7)+(2*5)+(1*5)=166
166 % 10 = 6
So 350797-55-6 is a valid CAS Registry Number.
350797-55-6Relevant articles and documents
Design, Synthesis, and Biological Evaluation of Indoline and Indole Derivatives as Potent and Selective α1A-Adrenoceptor Antagonists
Zhao, Fei,Li, Jing,Chen, Ying,Tian, Yanxin,Wu, Chenglin,Xie, Yanan,Zhou, Yu,Wang, Jiang,Xie, Xin,Liu, Hong
, p. 3826 - 3839 (2016/05/24)
A series of indoline and indole derivatives were designed, synthesized, and evaluated as selective α1A-adrenergic receptor (α1A-AR) antagonists for the treatment of benign prostatic hyperplasia (BPH). In this study, two highly selective and potent α1A-AR antagonists, compounds (R)-14r (IC50 = 2.7 nM, α1B/α1A = 640.1, α1D/α1A = 408.2) and (R)-23l (IC50 = 1.9 nM, α1B/α1A = 1506, α1D/α1A = 249.6), which exhibited similar activities and better selectivities in cell-based calcium assays as compared with the marketed drug silodosin (IC50 = 1.9 nM, α1B/α1A = 285.9, α1D/α1A = 14.4), were identified. In the functional assays with isolated rat tissues, compounds (R)-14r and (R)-23l also showed high potency and uroselectivity. Most importantly, (R)-14r and (R)-23l can significantly decrease the micturition frequency and increase the mean voided volume of the BPH rats in a dose-dependent manner, making them worthy of further investigation for the development of anti-BPH agents.
PROCESS FOR PREPARING AN INTERMEDIATE FOR SILODOSIN
-
, (2011/10/31)
The present invention provides a process for preparing a compound of formula (I), wherein R1 is a hydroxyl-protecting group and R2 is a cyano group or a carbamoyl group, wherein the process comprises the direct hydrogenation of the corresponding achiral nitro compound and the resolution of the racemic amino compound. The compound of formula (I) can easily be further transferred to silodosin.
