351-32-6

Basic information

• Product Name: N-(4-fluoro-3-nitrophenyl)acetamide
• Synonyms: N-(4-fluoro-3-nitrophenyl)acetamide;N-(3-Nitro-4-fluorophenyl)acetamide;N-(4-fluoro-3-nitro-phenyl)ethanamide;N-(4-Fluoro-3-nitrophenyl)acetamide, 5-(Acetylamino)-2-fluoronitrobenzene, 5-Acetamido-2-fluoronitrobenzene
• CAS NO: 351-32-6
• Molecular Formula: C₈H₇FN₂O₃
• Molecular Weight: 198.1511832
• EINECS: 206-510-1
• Mol File: 351-32-6.mol
• Article Data: 27

Chemical Properties

• Melting Point: 138.5 °C
• Boiling Point: 385.9°Cat760mmHg
• Flash Point: 187.2°C
• Appearance: /
• Density: 1.429g/cm³
• Vapor Pressure: 3.69E-06mmHg at 25°C
• Refractive Index: 1.594
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.18±0.70(Predicted)
• CAS DataBase Reference: N-(4-fluoro-3-nitrophenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-fluoro-3-nitrophenyl)acetamide(351-32-6)
• EPA Substance Registry System: N-(4-fluoro-3-nitrophenyl)acetamide(351-32-6)

Safety Data

• Hazardous Substances Data: 351-32-6(Hazardous Substances Data)

Usage

General Description

N-(4-fluoro-3-nitrophenyl)acetamide is a chemical compound characterized by its molecular structure composed of a fluoro-substituted nitrophenyl group attached to an acetamide backbone. N-(4-fluoro-3-nitrophenyl)acetamide is commonly used in organic synthesis and pharmaceutical research due to its potential as a building block for drug development and functional materials. It is also known for its antimicrobial and anti-inflammatory properties, making it a promising candidate for the development of new therapeutic agents. However, it is important to handle this compound with care and follow proper safety protocols, as it may pose health and environmental risks if not managed responsibly.

InChI:InChI=1/C8H7FN2O3/c1-5(12)10-6-2-3-7(9)8(4-6)11(13)14/h2-4H,1H3,(H,10,12)

Upstream product

• 364-76-1 4-Fluoro-3-nitroaniline 
• 75-36-5 acetyl chloride 
• 28166-06-5 4-fluoro-3-nitrophenylazide 
• 507-09-5 tiolacetic acid 
• 108-24-7 acetic anhydride 

Downstream Products

• 34572-59-3 4-acetylamino-N-(2-hydroxyethyl)-2-nitroaniline 
• 849351-15-1 N-ethyl-N-(4-fluoro-3-nitrophenyl) acetamide 
• 1344146-24-2 N-(4-oxo-5-(p-tolyl)-4,5-dihydropyrrolo[1,2-a]quinoxalin-7-yl)-acetamide 
• 952675-19-3 1-({2-tert-butyl-1-[(4-fluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}sulfonyl)-1H-pyrrole-3-carbaldehyde 
• 952675-18-2 2-tert-butyl-1-[(4-fluorocyclohexyl)methyl]-1H-benzimidazole-5-sulfonyl chloride 

Relevant articles and documents

Potential of 2-Chloro-N-(4-fluoro-3-nitrophenyl)acetamide against Klebsiella pneumoniae and in Vitro Toxicity Analysis

Klebsiella pneumoniae causes a wide range of community and nosocomial infections. The high capacity of this pathogen to acquire resistance drugs makes it necessary to develop therapeutic alternatives, discovering new antibacterial molecules. Acetamides are molecules that have several biological activities. However, there are no reports on the activity of 2-chloro-N-(4-fluoro-3-nitrophenyl)acetamide. Based on this, this study aimed to investigate the in vitro antibacterial activity of this molecule on K. pneumoniae, evaluating whether the presence of the chloro atom improves this effect. Then, analyzing its antibacterial action more thoroughly, as well as its cytotoxic and pharmacokinetic profile, in order to contribute to future studies for the viability of a new antibacterial drug. It was shown that the substance has good potential against K. pneumoniae and the chloro atom is responsible for improving this activity, stabilizing the molecule in the target enzyme at the site. The substance possibly acts on penicillin-binding protein, promoting cell lysis. The analysis of cytotoxicity and mutagenicity shows favorable results for future in vivo toxicological tests to be carried out, with the aim of investigating the potential of this molecule. In addition, the substance showed an excellent pharmacokinetic profile, indicating good parameters for oral use.

Therapeutic Compounds

Compounds of formula I or pharmaceutically acceptable salts thereof: wherein R1, R2, R3 and R4 are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

Benzimidazole Derivatives, Compositions Containing Them, Preparation Thereof and Uses Thereof

Compounds of Formula (I) or pharmaceutically acceptable salts thereof; wherein R1, R2, R3, and R4 are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.