351-61-1

Basic information

• Product Name: N-(2,2,2-trifluoroethyl)aniline
• Synonyms: N-(2,2,2-trifluoroethyl)aniline;N-(2,2,2-trifluoroethyl)aniline(SALTDATA: FREE)
• CAS NO: 351-61-1
• Molecular Formula: C₈H₈F₃N
• Molecular Weight: 175.17
• Mol File: 351-61-1.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 186°Cat760mmHg
• Flash Point: 66.3°C
• Appearance: /
• Density: 1.2327 (estimate)
• Vapor Pressure: 0.679mmHg at 25°C
• Refractive Index: 1.489
• PKA: 1.09±0.50(Predicted)
• CAS DataBase Reference: N-(2,2,2-trifluoroethyl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,2,2-trifluoroethyl)aniline(351-61-1)
• EPA Substance Registry System: N-(2,2,2-trifluoroethyl)aniline(351-61-1)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 351-61-1(Hazardous Substances Data)

Usage

Safety Profile

A poison by intraperitoneal andintravenous routes. When heated to decomposition itemits toxic vapors of NOx and F??.

InChI:InChI=1/C8H8F3N/c9-8(10,11)6-12-7-4-2-1-3-5-7/h1-5,12H,6H2

Upstream product

• 75-88-7 1,1,1-trifluoro-2-chloroethane 
• 62-53-3 aniline 
• 67-56-1 methanol 
• 55204-33-6 N-methyl-N-(2,2,2-trifluoroethyl)-aniline 
• 2325-27-1 N-phenyltriphenyliminophosphorane 
• 100422-07-9 2,2,2-trifluoroethyl(phenyl)iodonium trifluoromethanesulfonate 
• 371-67-5 2,2,2-trifluorodiazoethane 
• 373-88-6 2,2,2-trifluroethylamine hydrochloride 
• 753-90-2 trifluoroethylamine 
• 98-80-6 phenylboronic acid 
• 1547-96-2 2,4,6-tris(2,2,2-trifluoroethoxy)-1,3,5-triazine 
• 103-70-8 Formanilid 
• 93-98-1 N-phenyl benzoyl amide 
• 76-05-1 trifluoroacetic acid 

Downstream Products

• 324-48-1 3-[N-(2,2,2-trifluoro-ethyl)-anilino]-propan-1-ol 
• 50885-36-4 2-Fluoro-N-{2-[phenyl-(2,2,2-trifluoro-ethyl)-amino]-ethyl}-benzamide 
• 86099-79-8 2-cyclohexanone 
• 1158918-62-7 6-Chloro-N-phenyl-N-(2,2,2-trifluoroethyl)pyrimidine-4-carboxamide 
• 1404508-97-9 C₁₀H₁₀F₃NO₂S 

Relevant articles and documents

Iron porphyrin-catalyzedN-trifluoroethylation of anilines with 2,2,2-trifluoroethylamine hydrochloride in aqueous solution

An iron porphyrin-catalyzedN-trifluoroethylation of anilines has been developed with 2,2,2-trifluoroethylamine hydrochloride as the fluorine source. This one-pot N-H insertion reaction is conductedviacascade diazotization/N-trifluoroethylation reactions.

Direct N-Alkylation/Fluoroalkylation of Amines Using Carboxylic Acids via Transition-Metal-Free Catalysis

A scalable protocol of direct N-mono/di-alkyl/fluoroalkylation of primary/secondary amines has been constructed with various carboxylic acids as coupling agents under the catalysis of a simple air-tolerant inorganic salt, K3PO4. Advantageous features include 100 examples, 10 drugs and drug-like amines, fluorinated complex tertiary amines, gram-scale synthesis and isotope-labelling amine, thus demonstrating the potential applicability in industry of this methodology. The involvement of relatively less reactive silicon-hydride compared with the traditional reactive metal-hydride or boron-hydride species required to reduce the amide intermediates presumably contributes to the remarkable functional group compatibility. (Figure presented.).

Method of catalyzing trifluoro-ethylation of aromatic primary amine by ferriporphyrin

The invention provides a method of catalyzing trifluoro-ethylation of aromatic primary amine by ferriporphyrin. The method comprises the following steps: adding trifluoroethylamine salt and nitrite toa diazo-reaction first and then adding aromatic primary