3512-80-9Relevant articles and documents
Cis/trans isomerization of o -phosphino-arenesulfonate palladium methyl complexes
Zhou, Xiaoyuan,Lau, Ka-Cheong,Petro, Benjamin J.,Jordan, Richard F.
, p. 7209 - 7214 (2014)
The cis/trans isomerization of (PO-OMe)PdMe(lut) ([PO-OMe]- = 2-{P(2-OMe-Ph)2}-4-Me-benzenesulfonate) was studied to model the proposed isomerization in chain propagation in ethylene polymerization by (o-phosphino-arenesulfonate)PdR(ethylene) species. Nonequilibrium mixtures of cis-P,C- and trans-P,C-(PO-OMe)PdMe(2,6-lutidine) were generated by the reaction of Na[PO-OMe] and {Pd(μ-Cl)Me(2,6-lutidine)}2 in CD2Cl2 at -25 °C. Kinetic studies revealed lutidine-catalyzed and noncatalyzed isomerization pathways. The lutidine-catalyzed pathway involves five-coordinate (PO-OMe)PdMe(lut)2 intermediates that undergo Berry pseudorotation. Kinetic studies, structure-activity relationships, solvent effects, and density functional theory calculations for the noncatalyzed pathway are most consistent with a mechanism, originally proposed by Nozaki, Morokuma, and co-workers, which proceeds through a five-coordinate transition state with κ3-P,O,O coordination of the [PO]- ligand.
Preparation and purification method of toxic impurity DCAL of clopidol
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, (2018/04/03)
The invention relates to a preparation and purification method of toxic impurity DCAL of clopidol and belongs to the technical field of preparation of standard medicine products. The preparation and purification method comprises the following steps: firstly carrying out chlorination reaction, i.e., dissolving a solvent and 2,6-dimethyl-4-aminopyridine; then slowly adding a chlorinating agent to carry out chlorination; after reaction is finished, carrying out neutralization and water washing, concentration and crystallization, filtering or direct neutralization and filtering on reaction liquidto obtain a crude DCAL product; purifying the crude DCAL product, adding a mixed solvent of ethanol and ethyl acetate into the crude DCAL product, stirring for dissolving, dripping petroleum ether toprecipitate solids, filtering, carrying out concentration, cooling and precipitation on filtrate, then filtering, and drying solids to obtain a pure DCAL product. The preparation and purification method has the beneficial effects that the reaction temperature is low, the reaction time is short, the side products in reaction are fewer, and the product is easily purified, so that convenience is brought for preparing impurity reference products of the veterinary-drug clopidol.
1,1,1-TRIFLUORO-4-PHENYL-4-METHYL-2-(1H-PYRROLO
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Page/Page column 166-167, (2010/02/11)
Compounds of Formula (IA), IB), IC), and (ID) wherein R1, R2, R3, R4, R5, and R6 are as respectively defined herein for Formula (IA), (IB), (IC), and (ID), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.