35135-35-4Relevant articles and documents
Efficient Synthesis of (?)-Corynoline by Enantioselective Palladium-Catalyzed α-Arylation with Sterically Hindered Substrates
Rao, Xiaofeng,Li, Naikai,Bai, Heng,Dai, Chaodi,Wang, Zheng,Tang, Wenjun
supporting information, p. 12328 - 12332 (2018/09/18)
Sterically hindered substrates can be employed in an enantioselective palladium-catalyzed α-arylation with the chiral monophosphorus ligand BI-DIME. This process enabled an efficient synthesis of the antidepressant (S)-nafenodone, a four-step enantioselective synthesis of the Sceletium alkaloid (+)-sceletium A-4, a concise five-step enantioselective synthesis of (?)-corynoline, as well as a three-step preparation of (?)-DeN-corynoline.
First enantiocontrolled synthesis of sceletium alkaloid A-4: Determination of the absolute configuration
Kamikubo, Takashi,Ogasawara, Kunio
, p. 783 - 784 (2007/10/03)
Sceletium A-4, a pyridine alkaloid isolated from the Sceletium species, has been synthesized for the first time in an enantiocontrolled manner along with (-)-mesembrine, an alkaloid isolated from the same plant, starting from a chiral cyclohexadienone synthon to determine the absolute configuration.