35135-38-7

Basic information

• Product Name: 1,4-Naphthalenedione, 2-hydroxy-3-iodo-
• Synonyms: 2-iodo-3-hydroxy-1,4 naphthoquinone;2-hydroxy-3-iodo-[1,4]naphthoquinone;iodolawsone;3-iodolawsone;2-hydroxy-3-iodonaphthoquinone;3-iodo-2-hydroxy-1,4-naphthoquinone
• CAS NO: 35135-38-7
• Molecular Formula: C10H5IO3
• Molecular Weight: 300.052
• Mol File: 35135-38-7.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: 1,4-Naphthalenedione, 2-hydroxy-3-iodo-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Naphthalenedione, 2-hydroxy-3-iodo-(35135-38-7)
• EPA Substance Registry System: 1,4-Naphthalenedione, 2-hydroxy-3-iodo-(35135-38-7)

Safety Data

• Hazardous Substances Data: 35135-38-7(Hazardous Substances Data)

Usage

General Description

1,4-Naphthalenedione, 2-hydroxy-3-iodo- is a chemical compound that is also known as iodo hydroxyquinone, and it is a derivative of naphthoquinone. It is identified by its light yellow to yellow-brown appearance and is commonly used in organic synthesis and as a pharmaceutical intermediate. 1,4-Naphthalenedione, 2-hydroxy-3-iodo- is considered to be potentially harmful if ingested, inhaled, or comes into contact with the skin or eyes, and should be handled with caution. Its industrial applications include the manufacture of dyes, pigments, and pharmaceuticals, and it is also used as an intermediate in the production of other chemicals. Additionally, 1,4-Naphthalenedione, 2-hydroxy-3-iodo- has potential uses in the field of material science and nanochemistry due to its unique chemical properties and structure.

Upstream product

• 83-72-7 2-hydroxynaphtho-1,4-quinone 
• 571166-63-7 Z,E-3-iodo-4-hydroxy-1[(2-phenylethyl)imino]-2-naphthalenone 
• 106-49-0 p-toluidine 
• 572874-62-5 3-iodo-4-hydroxy-1,2-naphthoquinone 
• 117560-06-2 3-phenyliodonio-1,2,4-trioxo-1,2,3,4-tetrahydronaphthalenide 
• 74-88-4 methyl iodide 

Downstream Products

• 6628-97-3 2-(phenylamino)naphthoquinone 
• 886-66-8 1,4-diphenyl-1,3-butadiyne 
• 62452-63-5 2-phenylnaphtho[2,3-b]furan-4,9-dione 
• 655-86-7 2,3-diaminephenazine 
• 83-72-7 2-hydroxynaphtho-1,4-quinone 
• 105438-12-8 (E)-2-hydroxy-3-styrylnaphthalene-1,4-dione 
• 75204-51-2 2-phenylnaphtho[1,2-b]furan-4,5-dione 
• 10409-20-8 2-(4-chlorophenyl)-3-hydroxynaphthalene-1,4-dione 
• 1150-59-0 2-hydroxy-3-phenyl-1,4-naphthoquinone 

Relevant articles and documents

Lawsone, Juglone, and β-Lapachone Derivatives with Enhanced Mitochondrial-Based Toxicity

Naphthoquinones are among the most active natural products obtained from plants and microorganisms. Naphthoquinones exert their biological activities through pleiotropic mechanisms that include reactivity against cell nucleophiles, generation of reactive oxygen species (ROS), and inhibition of proteins. Here, we report a mechanistic antiproliferative study performed in the yeast Saccharomyces cerevisiae for several derivatives of three important natural naphthoquinones: lawsone, juglone, and β-lapachone. We have found that (i) the free hydroxyl group of lawsone and juglone modulates toxicity; (ii) lawsone and juglone derivatives differ in their mechanisms of action, with ROS generation being more important for the former; and (iii) a subset of derivatives possess the capability to disrupt mitochondrial function, with β-lapachones being the most potent compounds in this respect. In addition, we have cross-compared yeast results with antibacterial and antitumor activities. We discuss the relationship between the mechanistic findings, the antiproliferative activities, and the physicochemical properties of the naphthoquinones.

METHOD FOR PRODUCING 2-ALKYLCARBONYLNAPHTHO[2,3-b]FURAN-4,9-DIONE-RELATED SUBSTANCE, AND SAID RELATED SUBSTANCE

Provided is a method for producing a 2-alkylcarbonylnaphtho[2,3-b]furan-4,9-dione-related substance, which is suitable for the production on an industrial scale. The present invention provides: a method for producing an intermediate for the production of

1,4-Naphthoquinones potently inhibiting P2X7 receptor activity

P2X7 receptor (P2X7R) is an ATP-gated ion-channel with potential therapeutic applications. In this study, we prepared and searched a series of 1,4-naphthoquinones derivatives to evaluate their antagonistic effect on both human and murine P2X7 receptors. W