351378-72-8

Basic information

• Product Name: Phenol, 6-bromo-2,4-dimethoxy-3-methyl-
• CAS NO: 351378-72-8
• Molecular Formula: C9H11BrO3
• Molecular Weight: 247.089
• Mol File: 351378-72-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Phenol, 6-bromo-2,4-dimethoxy-3-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 6-bromo-2,4-dimethoxy-3-methyl-(351378-72-8)
• EPA Substance Registry System: Phenol, 6-bromo-2,4-dimethoxy-3-methyl-(351378-72-8)

Safety Data

• Hazardous Substances Data: 351378-72-8(Hazardous Substances Data)

Upstream product

• 96502-90-8 acetic acid 2,4-dimethoxy-3-methyl-phenyl ester 
• 5673-07-4 2,6-dimethoxytoluene 
• 60512-80-3 2′,4′-dimethoxy-3′-methylacetophenone 
• 7149-92-0 2,4-dimethoxy-3-methylbenzaldehyde 
• 19676-67-6 2,4-dimethoxy-3-methylphenol 

Downstream Products

• 1000880-09-0 1-bromo-2,3,5-trimethoxy-4-methylbenzene 
• 1339232-76-6 (S)-2-((tert-butyldiphenylsilyl)oxy)-1-(2,3,5-trimethoxy-4-methylphenyl)ethanol 
• 1339232-23-3 (R)-2-((tert-butyldiphenylsilyl)oxy)-1-(2,3,5-trimethoxy-4-methylphenyl)ethanamine 
• 1339232-77-7 (R)-2-((tert-butyldiphenylsilyl)oxy)-N-(4-methoxybenzyl)-1-(2,3,5-trimethoxy-4-methylphenyl)ethanamine 
• 1339232-80-2 (R)-N-(2-((tert-butyldiphenylsilyl)oxy)-1-(2,3,5-trimethoxy-4-methylphenyl)ethyl)-2-hydroxy-N-(4-methoxybenzyl)acetamide 
• 1339232-26-6 (R)-methyl 3-(((1R)-1-(((tert-butyldiphenylsilyl)oxy)methyl)-5,7,8-trimethoxy-2-(4-methoxybenzyl)-6-methyl-3-oxo-1,2,3,4-tetrahydroisoquinolin-4-yl)thio)-2-(((2,2,2-trichloroethoxy)carbonyl)amino)propanoate 
• 1339232-84-6 (R)-methyl 3-(((1R,4R)-1-(hydroxymethyl)-5,7,8-trimethoxy-2-(4-methoxybenzyl)-6-methyl-3-oxo-1,2,3,4-tetrahydroisoquinolin-4-yl)thio)-2-(((2,2,2-trichloroethoxy)carbonyl)amino)propanoate 
• 1339232-29-9 (R)-3-(((1R,4R)-1-(hydroxymethyl)-5,7,8-trimethoxy-2-(4-methoxybenzyl)-6-methyl-3-oxo-1,2,3,4-tetrahydroisoquinolin-4-yl)thio)-2-(((2,2,2-trichloroethoxy)carbonyl)amino)propanoic acid 
• 1339231-97-8 2,2,2-trichloroethyl ((1R,4R,8R)-9,10,12-trimethoxy-13-(4-methoxybenzyl)-11-methyl-5,14-dioxo-1,3,4,5,7,8-hexahydro-8,1-(epiminomethano)benzo[g][1,5]oxathiecin-4-yl)carbamate 
• 85071-59-6 1-bromo-2,3,5-trimethoxy-4-methylbenzaldehyde 
• 271578-78-0 1,3,4-trimethoxy-2-methyl-5-vinylbenzene 
• 271578-79-1 (S)-1-(2,3,5-Trimethoxy-4-methyl-phenyl)-ethane-1,2-diol 

Relevant articles and documents

Enantioselective Synthesis of (+)-Mitomycin K by a Palladium-Catalyzed Oxidative Tandem Cyclization

The mitomycins, a family of bioactive natural products, feature a compact 6/5/5-fused polycyclic ring structure densely decorated with highly reactive and/or fragile quinone, amino ketal, and aziridine as well as carbamate moieties. It is this striking feature that has defeated numerous synthetic attempts towards these apparently small molecules, rendering them one of the most formidable targets for total synthesis. We herein report the first enantioselective synthesis of (+)-mitomycin K, a representative of G series mitomycins. The key step of this synthesis is an enantioselective oxidative cyclization catalyzed by a palladium/(+)-sparteine system that had previously been developed by our group. The robustness of this method bodes well for further applications in the asymmetric total synthesis of natural products, particularly those with characteristic 6/5/5-fused pyrroloindole skeletons.

Studies directed to the total synthesis of ET 743 and analogues thereof: An expeditious route to the ABFGH subunit

(matrix presented) In model studies directed to the total synthesis of Et743, a strategic S-C bond formation in systems 26 and 27 was demonstrated. It was further shown that Pictet-Spengler cyclization leading to spiro product 33 exhibits very high stereo