351410-32-7

Basic information

• Product Name: (R)-2-CARBOXYMETHYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• Synonyms: 2-[(2R)-1-[(2-methylpropan-2-yl)oxycarbonyl]piperidin-2-yl]acetic acid;(R)-BOC-(2-CARBOXYMETHYL)-PIPERIDINE;(R)-(1-BOC-PIPERIDIN-2-YL)-ACETIC ACID;(R)-2-CARBOXYMETHYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;(R)-1-Boc-2-piperidineacetic acid;(R)-N-Boc-2-piperidine acetic acid;(R)-1-Boc-piperidin-2-ylacetic acid, (R)-N-Boc-2-carboxymethyl-piperidine;(R)-N-Boc-2-carboxyMethyl-piperidine
• CAS NO: 351410-32-7
• Molecular Formula: C₁₂H₂₁NO₄
• Molecular Weight: 243.3
• Product Categories: pharmacetical
• Mol File: 351410-32-7.mol
• Article Data: 3

Chemical Properties

• Melting Point: 93-97 °C
• Boiling Point: 373 °C at 760 mmHg
• Flash Point: 179.4 °C
• Appearance: /
• Density: 1.121 g/cm³
• Vapor Pressure: 1.37E-06mmHg at 25°C
• Refractive Index: 1.486
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (R)-2-CARBOXYMETHYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-CARBOXYMETHYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(351410-32-7)
• EPA Substance Registry System: (R)-2-CARBOXYMETHYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(351410-32-7)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 351410-32-7(Hazardous Substances Data)

Usage

Chemical Properties

White powder

InChI:InChI=1/C12H21NO4/c1-12(2,3)17-11(16)13-7-5-4-6-9(13)8-10(14)15/h9H,4-8H2,1-3H3,(H,14,15)/t9-/m1/s1

Upstream product

• 639458-46-1 (R)-2-(2-oxo-ethyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 1000806-51-8 (E)-(7-tert-butoxycarbonylamino)-2-heptenal 
• 327158-13-4 (R)-6-Allyl-1-[(R)-1-(2-hydroxy-phenyl)-ethyl]-piperidin-2-one 
• 327158-15-6 {(R)-1-[(R)-1-(2-Methoxy-phenyl)-ethyl]-6-oxo-piperidin-2-yl}-acetaldehyde 
• 327158-11-2 1-[(R)-1-(2-Hydroxy-phenyl)-ethyl]-piperidine-2,6-dione 
• 327158-12-3 (9aS,10R)-10-Methyl-1,2,3,9a-tetrahydro-10H-9-oxa-4a-aza-anthracen-4-one 
• 68419-38-5 (2R)-2-(2-methoxyethyl)piperidine 
• 108-55-4 glutaric anhydride, 
• 24424-99-5 di-tert-butyl dicarbonate 
• 19832-04-3 (R)-2-(piperidin-2'-yl)ethanoic acid 
• 250249-85-5 (R)-2-(2-hydroxy-ethyl)-piperidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 1277168-71-4 C₉H₁₈N₂ 
• 486-70-4 lupinine 
• 26892-59-1 epilupininic acid 
• 813433-73-7 (R)-2-methoxycarbonylmethylpiperidine-1-carboxylic acid tert-butyl ester 
• 639458-46-1 (R)-2-(2-oxo-ethyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 250249-85-5 (R)-2-(2-hydroxy-ethyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 905716-97-4 tert-butyl 2-(2-oxo-4-phenylbut-3-ynyl)piperidine-1-carboxylate 
• 905717-32-0 4-phenyl-7,8,9,9a-tetrahydro-1H-quinolizin-2(6H)-one 

Relevant articles and documents

Organocatalytic enantioselective synthesis of quinolizidine alkaloids (+)-myrtine, (-)-lupinine, and (+)-epiepiquinamide

The organocatalytic synthesis of quinolizidine alkaloids (+)-myrtine, (-)-lupinine, and (+)-epiepiquinamide is described. It involved, as the key step, an enantioselective intramolecular aza-Michael reaction (IMAMR) catalyzed by J?rgensen catalyst I, affording the common precursor with high enantioselectivity. This compound was subsequently transformed into the three alkaloids in a highly diastereoselective manner.

Total synthesis of (-)-stellettamide B and determination of its absolute stereochemistry.

[figure: see text] The first total synthesis of (-)-stellettamide B has been achieved by a sequence based on amide coupling of the chiral 1-(aminomethyl)-indolizidine fragment, prepared by TiCl4-mediated asymmetric allylation of the tricyclic N-acyl-N,O-a