351498-10-7

Basic information

• Product Name: N,N'-BIS(3,5-DI-TERT-BUTYLSALICYLIDENE)-1,1,2,2-TETRAMETHYLETHYLENEDIAMINE
• Synonyms: N,N'-BIS(3,5-DI-TERT-BUTYLSALICYLIDENE)-1,1,2,2-TETRAMETHYLETHYLENEDIAMINE;2-((E)-(3-((E)-3,5-di-tert-butyl-2-hydroxybenzylideneamino)-2,3-dimethylbutan-2-ylimino)methyl)-4,6-di-tert-butylphenol;6,6'-((1E,1'E)-((2,3-diMethylbutane-2,3-diyl)bis(azanylylidene))bis(Methanylylidene))bis(2,4-di-tert-butylphenol);2-((E)-(3-((E)-3,5-di-tert-butyl-2-hydroxybenzylideneaMino);6,6'-((1E,1'E)-((2,3-Dimethylbutane-2,3-diyl)bis(azanylylidene))-bis(methanylylidene))bis(2,4-di-;N,N'-Bis(3,5-di-tert-butylsalicylidene)-1,1,2,2-tetramethylethylenediamine;6,6'-((1E,1'E)-((2,3-Dimethylbutane-2,3-diyl)bis(azanylylidene))-bis(methanylylidene))bis(2,4-;2,2-[(1,1,2,2-Tetramethyl-1,2-ethanediyl)bis(nitrilomethylidyne)]bis[4,6-bis(1,1-dimethylethyl)phenol
• CAS NO: 351498-10-7
• Molecular Formula: C₃₆H₅₆N₂O₂
• Molecular Weight: 548.84
• Mol File: 351498-10-7.mol
• Article Data: 0

Chemical Properties

• Melting Point: 201.0 to 205.0 °C
• Boiling Point: 592.122°C at 760 mmHg
• Flash Point: 403.899°C
• Appearance: /
• Density: 0.952g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.506
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: within almost transparency in THF
• PKA: 14.43±0.50(Predicted)
• CAS DataBase Reference: N,N'-BIS(3,5-DI-TERT-BUTYLSALICYLIDENE)-1,1,2,2-TETRAMETHYLETHYLENEDIAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: N,N'-BIS(3,5-DI-TERT-BUTYLSALICYLIDENE)-1,1,2,2-TETRAMETHYLETHYLENEDIAMINE(351498-10-7)
• EPA Substance Registry System: N,N'-BIS(3,5-DI-TERT-BUTYLSALICYLIDENE)-1,1,2,2-TETRAMETHYLETHYLENEDIAMINE(351498-10-7)

Safety Data

• Hazardous Substances Data: 351498-10-7(Hazardous Substances Data)

Usage

Description

N,N'-BIS(3,5-DI-TERT-BUTYLSALICYLIDENE)-1,1,2,2-TETRAMETHYLETHYLENEDIAMINE, also known as 6,6''-((1E,1''E)-((2,3-Dimethylbutane-2,3-diyl)bis(azanylylidene))bis(methanylylidene))bis(2,4-di-tert-butylphenol), is a complex organic compound with a unique structure characterized by its two bulky tert-butylphenol groups connected through a tetramethylene ethylenediamine bridge. N,N'-BIS(3,5-DI-TERT-BUTYLSALICYLIDENE)-1,1,2,2-TETRAMETHYLETHYLENEDIAMINE is known for its stability and reactivity, making it a valuable building block in various chemical applications.

Uses

Used in Catalyst Preparation:
N,N'-BIS(3,5-DI-TERT-BUTYLSALICYLIDENE)-1,1,2,2-TETRAMETHYLETHYLENEDIAMINE is used as a building block for the preparation of cobalt catalysts. These catalysts are specifically designed for the hydrochlorination of unactivated olefins, a chemical reaction that involves the addition of hydrogen chloride (HCl) to an olefin, resulting in the formation of chloroalkanes. The unique structure of this compound contributes to the enhanced catalytic activity and selectivity of the resulting cobalt catalysts.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, N,N'-BIS(3,5-DI-TERT-BUTYLSALICYLIDENE)-1,1,2,2-TETRAMETHYLETHYLENEDIAMINE is used as a key intermediate in the synthesis of 11β hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors. 11β-HSD1 is an enzyme that plays a crucial role in the regulation of glucocorticoid hormones, which are involved in various physiological processes, including glucose metabolism, inflammation, and immune response. Inhibition of this enzyme has been shown to have potential therapeutic benefits in the treatment of metabolic disorders, such as type 2 diabetes and obesity. The use of this compound in the development of 11β-HSD1 inhibitors highlights its importance in the pharmaceutical sector for the creation of novel and effective therapeutic agents.

InChI:InChI=1/C36H56N2O2/c1-31(2,3)25-17-23(29(39)27(19-25)33(7,8)9)21-37-35(13,14)36(15,16)38-22-24-18-26(32(4,5)6)20-28(30(24)40)34(10,11)12/h17-22,39-40H,1-16H3/b37-21+,38-22+

Downstream Products

• 157472-96-3 [N,N'-(1,1,2,2-tetramethylethylene)bis(3,5-di-tert-butylsalicylideneiminato)]cobalt(II) 
• 157472-96-3 [N,N'-(1,1,2,2-tetramethylene)bis(3,5-di-tert-butylsalicylideneiminato)]cobalt(II)