352-13-6

Basic information

• Product Name: 4-FLUOROPHENYLMAGNESIUM BROMIDE
• Synonyms: 4-FLUOROPHENYLMAGNESIUM BROMIDE;4-FLUOROPHENYLMAGNESIUM BROMIDE, 2M IN DIETHYL ETHER;4-fluorophenylmagnesiumbromidesol.;4-FLUOROPHENYLMAGNESIUM BROMIDE, 2.0M SO LUTION IN DIETHYL ETHER;4-FLUOROPHENYLMAGNESIUM BROMIDE SOL., ~2 .0 M IN DIETHYL ET;4-FLUOROPHENYLMAGNESIUM BROMIDE, 1.0M SO LUTION IN TETRAHYDROFURAN;4-FLUOROPHENYLMAGNESIUM BROMIDE SOL., ~1 M IN THF;4-Fluorophenylmagnesium Bromide 1.0 M In Tetrahydrofuran
• CAS NO: 352-13-6
• Molecular Formula: C₆H₄BrFMg
• Molecular Weight: 199.3
• EINECS: 1592732-453-0
• Product Categories: Grignard Reagents;Aryl;Organometallic Reagents;Grignard Reagent
• Mol File: 352-13-6.mol
• Article Data: 37

Chemical Properties

• Melting Point: 5 °C
• Boiling Point: 66°C
• Flash Point: −40 °F
• Appearance: Clear yellow to red-brown/Solution
• Density: 1.043 g/mL at 25 °C
• Storage Temp.: Flammables + water-Freezer (-20°C)e area
• Water Solubility: It reacts violently with water.
• Sensitive: Air & Moisture Sensitive
• BRN: 636802
• CAS DataBase Reference: 4-FLUOROPHENYLMAGNESIUM BROMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUOROPHENYLMAGNESIUM BROMIDE(352-13-6)
• EPA Substance Registry System: 4-FLUOROPHENYLMAGNESIUM BROMIDE(352-13-6)

Safety Data

• Hazard Codes: F+,C,F
• Statements: 12-14-22-34-66-67-11-40-37-19
• Safety Statements: 16-26-36/37/39-43-45-7/8-33-8-7
• RIDADR: UN 2924 3/PG 2
• WGK Germany: 1
• F: 10-21
• TSCA: Yes
• HazardClass: 3
• PackingGroup: II
• Hazardous Substances Data: 352-13-6(Hazardous Substances Data)

Usage

Chemical Properties

clear yellow to red-brown solution

Uses

Different sources of media describe the Uses of 352-13-6 differently. You can refer to the following data:
1. 4-Fluorophenylmagnesium bromide is used as a reagent for the introduction of the 4-Fluorophenyl group.
2. 4-Fluorophenylmagnesium bromide solution (Grignard reagent) can be used as a reagent in the synthesis of:Useful key intermediate in the synthesis of paroxetine.Arylsulfides via cross-coupling reaction with thiols.4-Arylmethyl-1-phenylpyrazole and 4-aryloxy-1-phenylpyrazole derivatives as androgen receptor antagonists.Grignard intermediate for preparing aprepitant.

InChI:InChI=1/C6H4F.BrH.Mg/c7-6-4-2-1-3-5-6;;/h2-5H;1H;/q;;+1/p-1/rC6H4FMg.BrH/c7-5-1-3-6(8)4-2-5;/h1-4H;1H/q+1;/p-1

Upstream product

• 101990-15-2 4-chlorophenyl 1-(1,2,4-triazol-1-yl)-cyclopropyl ketone 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 352-34-1 4-fluoro-1-iodobenzene 
• 1068-55-9 isopropylmagnesium chloride 
• 207683-94-1 5-acetamido-phthalide 
• 109-54-6 3-(Dimethylamino)propyl chloride 
• 65399-05-5 5-amino-3H-isobenzofuran-1-one 
• 15721-22-9 2,2-dimethylvaleroyl chloride 
• 78444-54-9 2-(2,4-dichloro-6-methoxyphenyl)-4,5-dihydro-4,4-dimethyloxazole 
• 3612-18-8 N-ethyl-4-piperidone 
• 7439-95-4 magnesium 

Downstream Products

• 7589-27-7 2-(4-Fluorophenyl)ethanol 
• 403-41-8 1-(4-Fluorophenyl)ethanol 
• 345-83-5 4-fluorobenzophenone 
• 459-03-0 4-fluorophenyl acetone 
• 350-40-3 2-(4-fluorophenyl)-1-propene 
• 1496-36-2 1-(4-fluorophenyl)cyclohexan-1-ol 
• 1737-16-2 1-allyl-4-fluorobenzene 
• 54040-88-9 (3-Chloro-propyl)-(4-fluoro-phenyl)-dimethyl-silane 
• 7035-28-1 5-Chlor-1,1-bis-(4-fluorphenyl) pentanol 
• 16666-07-2 1,1-Bis-(4-fluor-phenyl)-2,2-dichlor-2-fluor-ethanol-1 
• 36029-75-1 α-(Chlordifluormethyl)-p-fluor-α-(trifluormethyl)-benzylalkohol 
• 73162-19-3 N'-Ethyliden-p,p'-difluorphenylglycolohydrazid 
• 73162-23-9 Bis-(4-fluoro-phenyl)-hydroxy-acetic acid N'-[1-(4-fluoro-phenyl)-ethyl]-hydrazide 
• 93436-58-9 dl-5-Chlor-1-(4-fluorphenyl)-1-phenyl-pentanol 

Relevant articles and documents

Processes for the Preparation of Zuclomiphene and Intermediates Thereof

The present invention provides processes for the preparation of zuclomiphene, as well as intermediates useful in the preparation thereof. In particular, processes are provided for the carbometallation of diphenylacetylene with a compound of Formula (3) to afford either zuclomiphene or an intermediate which is converted to zuclomiphene.

Nickel-Catalyzed Cross-Coupling of Functionalized Organo manganese Reagents with Aryl and Heteroaryl Halides Promoted by 4-Fluorostyrene

A catalytic system consisting of Ni(acac) 2 (5 mol%) and 4-fluorostyrene (20 mol%) allows a convenient cross-coupling of functionalized organomanganese reagents with a variety of aryl and heteroaryl halides leading to polyfunctionalized diaryl- and arylheteroarylmethane derivatives.

Nickel-Catalyzed Asymmetric Kumada Cross-Coupling of Symmetric Cyclic Sulfates

Nickel-catalyzed enantioselective cross-couplings between symmetric cyclic sulfates and aromatic Grignard reagents are described. These reactions are effective with a broad range of substituted cyclic sulfates and deliver products with asymmetric tertiary carbon centers. Mechanistic experiments point to a stereoinvertive SN2-like oxidative addition of a nickel complex to the electrophilic substrate.