352018-98-5

Basic information

• Product Name: 4-CYCLOPROPYL-5-(4-METHYL-1,2,3-THIADIAZOL-5-YL)-4H-1,2,4-TRIAZOLE-3-THIOL
• Synonyms: 4-CYCLOPROPYL-5-(4-METHYL-1,2,3-THIADIAZOL-5-YL)-4H-1,2,4-TRIAZOLE-3-THIOL
• CAS NO: 352018-98-5
• Molecular Formula: C₈H₉N₅S₂
• Molecular Weight: 239.32
• Mol File: 352018-98-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 212℃
• Boiling Point: 462.1°C at 760 mmHg
• Flash Point: 233.3°C
• Appearance: /
• Density: 1.87g/cm³
• Vapor Pressure: 1.01E-08mmHg at 25°C
• Refractive Index: 1.976
• PKA: 7.09±0.20(Predicted)
• CAS DataBase Reference: 4-CYCLOPROPYL-5-(4-METHYL-1,2,3-THIADIAZOL-5-YL)-4H-1,2,4-TRIAZOLE-3-THIOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CYCLOPROPYL-5-(4-METHYL-1,2,3-THIADIAZOL-5-YL)-4H-1,2,4-TRIAZOLE-3-THIOL(352018-98-5)
• EPA Substance Registry System: 4-CYCLOPROPYL-5-(4-METHYL-1,2,3-THIADIAZOL-5-YL)-4H-1,2,4-TRIAZOLE-3-THIOL(352018-98-5)

Safety Data

• Safety Statements: S24/25:Avoid contact with skin and eyes.
• Hazardous Substances Data: 352018-98-5(Hazardous Substances Data)

Usage

General Description

4-CYCLOPROPYL-5-(4-METHYL-1,2,3-THIADIAZOL-5-YL)-4H-1,2,4-TRIAZOLE-3-THIOL is an organic compound with a complex structure that includes cyclopropyl, thiadiazolyl, triazole, and thiol functional groups. It is a potential drug candidate with various biological activities, including antifungal and antibacterial properties. 4-CYCLOPROPYL-5-(4-METHYL-1,2,3-THIADIAZOL-5-YL)-4H-1,2,4-TRIAZOLE-3-THIOL has the potential to be used in the pharmaceutical industry for the development of new drugs to treat infections or as a research tool in organic chemistry. Further studies on its properties and potential applications may provide valuable insights into its medical and industrial uses.

InChI:InChI=1/C8H9N5S2/c1-4-6(15-12-9-4)7-10-11-8(14)13(7)5-2-3-5/h5H,2-3H2,1H3,(H,11,14)

Upstream product

• 1393674-29-7 N-cyclopropyl-2-(4-methyl-1,2,3-thiadiazole-5-carbonyl)hydrazinecarbothioamide 

Downstream Products

• 1352551-58-6 C₁₅H₁₄FN₅S₂ 
• 1352551-70-2 3-(((4-cyclopropyl-5-(4-methyl-1,2,3-thiadiazol-5-yl)-4H-1,2,4-triazol-3-yl)thio) methyl) benzonitrile 
• 1352551-69-9 5-(5-(benzylthio)-4-cyclopropyl-4H-1,2,4-triazol-3-yl)-4-methyl-1,2,3-thiadiazole 
• 1352551-67-7 5-(4-cyclopropyl-5-((4-methoxybenzyl)thio)-4H-1,2,4-triazol-3-yl)-4-methyl-1,2,3-thiadiazole 
• 1352551-64-4 5-(5-((4-(tert-butyl)benzyl)thio)-4-cyclopropyl-4H-1,2,4-triazol-3-yl)-4-methyl-1,2,3-thiadiazole 
• 1352551-62-2 5-(4-cyclopropyl-5-((3,4-dichlorobenzyl)thio)-4H-1,2,4-triazol-3-yl)-4-methyl-1,2,3-thiadiazole 
• 1352551-61-1 5-(4-cyclopropyl-5-((2,4-dichlorobenzyl)thio)-4H-1,2,4-triazol-3-yl)-4-methyl-1,2,3-thiadiazole 
• 1352551-65-5 5-(5-((4-chlorobenzyl)thio)-4-cyclopropyl-4H-1,2,4-triazol-3-yl)-4-methyl-1,2,3-thiadiazole 
• 1352551-63-3 5-(5-((3-chlorobenzyl)thio)-4-cyclopropyl-4H-1,2,4-triazol-3-yl)-4-methyl-1,2,3-thiadiazole 
• 1352551-68-8 5-(5-((2-chlorobenzyl)thio)-4-cyclopropyl-4H-1,2,4-triazol-3-yl)-4-methyl-1,2,3-thiadiazole 

Relevant articles and documents

Synthesis, Crystal Structure, and Biological Activity of Some Novel Sulfoxide Compounds Containing 1,2,3-Thiadiazole Moiety

Some new sulfoxide compounds containing 1,2,3-thiadiazole moiety were synthesized from diethyl carbonate and hydrazine hydrate by multi-step reactions. Their structures were confirmed by NMR, MS, and elemental analysis. One of the title compounds, 5-(4-cyclopropyl-5-((3-fluorobenzyl)sulfinyl)-4H-1,2,4-triazol-3-yl)-4-methyl-1,2,3-thiadiazole (C15H14FN5OS2), was structurally determined by a single crystal X-ray diffraction study. The biological activity of the title compound was determined, and the results showed that it displays moderate biological activities.

Synthesis, crystal structure, and biological activity of a novel 1,2,3-thiadiazole compound containing 1,2,4-triazole moiety

A new 1,2,3-thiadiazole compound containing 1,2,4-triazole moiety, C1 5H14FN5 O2S2, has been synthesized and the crystal structure was determined by single crystal X-ray diffraction study. The biological activity of the title compound was determined and the results showed that title compounds 10 showed higher inhibition abilities of rape root than the control cyclopropane-1,1-dicarboxylic acid at 100 μg/mL (73%) and weak activity against Echinochloa crusgalli (28%) and KARI (35%) at 100 μg/mL. [Supplementary materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements for the following free supplemental files: additional text, figures, tables.]