352214-93-8

Basic information

• Product Name: 2-AMINO-5,6-DIFLUOROBENZOTHIAZOLE
• Synonyms: 2-AMINO-5,6-DIFLUOROBENZOTHIAZOLE;2-Benzothiazolamine,5,6-difluoro-(9CI);5,6-Difluorobenzo[d]thiazol-2-amine
• CAS NO: 352214-93-8
• Molecular Formula: C₇H₄F₂N₂S
• Molecular Weight: 186.18
• Product Categories: BENZOTHIAZOLE
• Mol File: 352214-93-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 318.02 °C at 760 mmHg
• Flash Point: 146.134 °C
• Appearance: /
• Density: 1.592 g/cm³
• CAS DataBase Reference: 2-AMINO-5,6-DIFLUOROBENZOTHIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-5,6-DIFLUOROBENZOTHIAZOLE(352214-93-8)
• EPA Substance Registry System: 2-AMINO-5,6-DIFLUOROBENZOTHIAZOLE(352214-93-8)

Safety Data

• Hazardous Substances Data: 352214-93-8(Hazardous Substances Data)

Usage

General Description

2-Amino-5,6-difluorobenzothiazole is a chemical compound with the molecular formula C7H4F2N2S. It is a heterocyclic aromatic compound containing a benzene ring fused to a thiophene ring and substituted with amino and fluorine groups. 2-AMINO-5,6-DIFLUOROBENZOTHIAZOLE is used in organic synthesis, particularly in the preparation of pharmaceuticals and agrochemicals. It is also an important building block for the synthesis of various functional materials. 2-Amino-5,6-difluorobenzothiazole exhibits biological activity, and its derivatives have been investigated for their potential applications in drug discovery and development. Overall, this compound has several industrial and scientific applications and is an important intermediate in the synthesis of various valuable products.

Upstream product

• 1147550-11-5 ammonium thiocyanate 
• 3863-11-4 3,4-difluoroaniline 

Downstream Products

• 1430750-41-6 tert-butyl 3-(1-benzyl-1H-pyrazol-4-yl)-6-(8-(5,6-difluorobenzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)picolinate 
• 960535-39-1 C₇H₂ClF₂NS 
• 1374820-31-1 C₁₇H₁₅Cl₂F₂N₃S 
• 912273-97-3 N-(5,6-difluoro-1,3-benzothiazol-2-yl)-2,3,4,5-tetrafluorobenzamide 
• 131105-93-6 4,5-difluoro-2-aminothiophenol 

Relevant articles and documents

PHENYLIMIDE-CONTAINING BENZOTHIAZOLE DERIVATIVE OF ITS SALT AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

Provided is a phenylimide-containing benzothiazole derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, and a pharmaceutical composition comprising the same. The phenylimide-containing benzothiazole derivative or its pharmaceutically acceptable salt can selectively inhibit the protein-protein interaction between KRS and a laminin receptor (LR), thereby inhibiting migration of cancer cells. Therefore, the phenylimide-containing benzothiazole derivative or its pharmaceutically acceptable salt may be usefully applied for preventing or treating the diseases associated with cancer cell metastasis.

Preparation, antibacterial evaluation and preliminary structure-activity relationship (SAR) study of benzothiazol- and benzoxazol-2-amine derivatives

In this study, a novel benzothiazol- and benzooxazol-2-amine scaffold with antibacterial activity was designed and synthesized. Preliminary structure-activity relationship analysis displayed that compound 8t with a 5,6-difluorosubstituted benzothiazole was found to be a potent inhibitor of Gram-positive pathogens, and exhibited some potential against drug-resistant bacteria and without cytotoxicity in therapeutic concentrations. In addition, molecular docking studies indicated that Staphylococcus aureus methionyl-tRNA synthetase might be the possible target of these compounds. Taken together, the present study provides an effective entry to the synthesis of a good lead for subsequent optimization and a new small molecule candidate drug for antibacterial therapeutics.

Synthesis of some 5-nitro-2-furfurylidene derivatives and their antibacterial and antifungal activities

A number of new 5-nitro-2-furfurylidene derivatives 9a-k were synthesized by the reaction of 2-methyl-4-(5-nitro-2-furfurylmethyliden)-Δ2-oxazolin-5-one 6 or 2-phenyl-4-(2-furfurylmethyliden)-Δ2-oxazolin-5-one 7 with appropriate 2-aminobenzothiazole. The compounds synthesized were identified by 1H-NMR, IR, MS and micro analysis. All compounds studied in this work were screened for their in vitro antimicrobial and antifungal activities against the standard strains: Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhimurium, and the yeast Candida albicans.