35225-79-7Relevant articles and documents
Incorporation of nanosized ZnWO4 and Fe3O4 on graphitic carbon nitride to fabricate a novel, highly active magnetically recoverable catalyst in Claisen–Schmidt condensation
Paul, Arijita,Devi, Meghali,Dhar, Siddhartha Sankar
, (2020)
Herein we outline a facile and viable approach for successful anchoring of ZnWO4 and Fe3O4 nanoparticles on graphitic carbon nitride (g-C3N4) through ultrasonication and microwave irradiation. The as-synthesised nanocomposite, g-C3N4–Fe3O4–ZnWO4, was characterised using Fourier transmission infrared spectroscopy, X-ray diffraction, scanning electron microscopy, energy-dispersive X-ray spectroscopy, transmission electron microscopy, vibrating-sample magnetometry, and X-ray photoelectron spectroscopy techniques. The nanocomposite exhibited appreciable catalytic performance in the Claisen–Schmidt condensation reaction between benzaldehyde and acetone producing dibenzalacetone with excellent yields. The as-prepared catalyst demonstrated excellent magnetically recyclable property for seven successive runs. The presence of g-C3N4 in the nanocomposite g-C3N4–Fe3O4–ZnWO4 played a significant role in promoting the catalytic activity due to its inherent basic nature and efficient grafting of the substrates onto the g-C3N4 sheets.
Synthesis, characterization and evaluation of topical antiinflammatory activity of dimethyl 4-oxo-2,6-diphenylcyclohexane-1,1-dicarboxylate
Al Ugla, Mazin Nadhim Mousa
, p. 2366 - 2368 (2013)
An attempt was made to synthesize a topical preparation of an active compound that has a potent antiinflammatory activity. Dimethyl 4- oxo-2,6-diphenylcyclohexane-1,1-dicarboxylate (II) was prepared by aldol condensation of benzaldehyde and acetone followed by Michael addition of dimethyl malonate. The optimum concentration of the compound was determined by comparing the antiinflammatory effect of ointment preparations at different concentrations. The antiinflammatory effects were studied by using carrageenan-induced paw edema method in rat and xylene induced rat ear edema. Good effect was observed with ointment containing 4 % and 5 % of the compound II concentration. The results showed that the drug had an obvious antiinflammatory effect as an external preparation and the activity is comparable to that of the standard ointment.
Stereoselective synthesis, spectral characterization, docking and biological screening of coumarin derivatives
Afzal, Zakia,Nadeem, Humaira,Rashid, Naghmana
, p. 330 - 341 (2021/07/19)
The compounds being synthesized in present research are chiral in nature so for getting enantiopure compounds, stereoselective synthesis was carried out by organocatalysis. The importance of enantiopure compounds can not be overstated because the living systems are chiral in nature and response of enantiomers can be very different in living systems. The organocatalysed synthesis was accumplished using 4-hydroxycoumarin and variously substituted dibenzylideneacetones as reactants and the organocatalyst being used was 9-amino-9-deoxyepiquinine. The range of enantioselectivity achieved was 24-95%. The synthesized compounds were characterized by UV, IR, 1H NMR, 13C NMR, EIMS, UVCD, VCD and Chiral HPLC. The major focus of this research was to develop anticoagulant compounds and therefore the molecular docking studies were carried out with crystal structure of vitamin k epoxide reductase (3kp9) and then screened for in-vitro anticoagulant activity by using warfarin as positive control. Out of six synthesized compounds, four compounds (1,2,5,6) have shown greater binding affinity with 3kp9 than warfarin. In in-vitro anticoagulant studies, all compounds showed improved IC50 values than warfarin. Besides anticoagulant activity, antimocrobial activities were also carried out with six different strains of bacteria and fungi. Compound (5) showed 79% inhibition against Bacillus subtillis and 62 % inhibition against Staphylococcus aureus.
Bu4NHSO4-Catalyzed Direct N-Allylation of Pyrazole and its Derivatives with Allylic Alcohols in Water: A Metal-Free, Recyclable and Sustainable System
Zhuang, Hongfeng,Lu, Nan,Ji, Na,Han, Feng,Miao, Chengxia
supporting information, p. 5461 - 5472 (2021/09/29)
Allylic amines are valuable and functional building blocks. Direct N-allylation of pyrazole and its derivatives as an atom economic strategy to provide allylic amines has been achieved only using commercial Bu4NHSO4 as the metal-free catalyst and water as the solvent without any additives. 11–93% isolated yields were obtained for the N-allylation of pyrazole and its derivatives with allylic alcohols. Bu4NHSO4 could be reused for six times by simple extraction nearly without loss of catalytic activity and was also suitable for a gram-scale production. The reaction of allylic ether and pyrazole did not occur to give the desired product indicated that allylic ether was not the active intermediate in the pathway. Density functional theory (DFT) calculations reveal that there are hydrogen bonding effects among substrates, solvent and catalyst, especially the one formed between allylic alcohol and H2O. Control experiments in different protic solvents further demonstrate the intermolecular hydrogen bonding of allylic alcohol and water. (Figure presented.).