352535-81-0 Usage
General Description
4-Bromo-2,6-difluorophenylboronic acid is a synthetic chemical compound categorized under the organoboron compounds. This molecule contains the elements boron, bromine, and fluorine. It's widely used in organic chemistry for various reactions, including Suzuki coupling, which is an important type of cross-coupling reactions used to build complex organic molecules. The bromo and fluoro substitutions on the phenyl ring of the compound contribute to its reactivity. Usually existing in a white or off-white powder form, this chemical has to be handled with care and under controlled conditions due to its corrosive nature and potential to cause skin and eye irritation.
Check Digit Verification of cas no
The CAS Registry Mumber 352535-81-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,5,2,5,3 and 5 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 352535-81:
(8*3)+(7*5)+(6*2)+(5*5)+(4*3)+(3*5)+(2*8)+(1*1)=140
140 % 10 = 0
So 352535-81-0 is a valid CAS Registry Number.
InChI:InChI=1/C6H4BBrF2O2/c8-3-1-4(9)6(7(11)12)5(10)2-3/h1-2,11-12H
352535-81-0Relevant articles and documents
Modular Generation of (Iodinated) Polyarenes Using Triethylgermane as Orthogonal Masking Group
Deckers, Kristina,Fricke, Christoph,Hupperich, Daniel,Kreisel, Tatjana,Mendel, Marvin,Queen, Adele E.,Riegger, Julian,Schoenebeck, Franziska
supporting information, (2022/03/31)
While the modular construction of molecules from suitable building blocks is a powerful means to more rapidly generate a diversity of molecules than through customized syntheses, the further evolution of the underlying coupling methodology is key to realize widespread applications. We herein disclose a complementary modular coupling approach to the widely employed Suzuki coupling strategy of boron containing precursors, which relies on organogermane containing building blocks as key orthogonal functionality and an electrophilic (rather than nucleophilic) unmasking event paired with air-stable PdI dimer based bond construction. This allows to significantly shorten the reaction times for the iterative coupling steps and/or to close gaps in the accessible compound space, enabling straightforward access also to iodinated compounds.
