3527-63-7

Basic information

• Product Name: (S)-2-Cyclohexyl-propionic acid
• Synonyms: (S)-2-Cyclohexyl-propionic acid;(S)-2-Cyclohexylpropanoic acid
• CAS NO: 3527-63-7
• Molecular Formula: C₉H₁₆O₂
• Molecular Weight: 156.22214
• Mol File: 3527-63-7.mol
• Article Data: 3

Chemical Properties

• Melting Point: 46-47 °C
• Boiling Point: 95 °C(Press: 0.2 Torr)
• Appearance: /
• Density: 1.019±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.79±0.10(Predicted)
• CAS DataBase Reference: (S)-2-Cyclohexyl-propionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-Cyclohexyl-propionic acid(3527-63-7)
• EPA Substance Registry System: (S)-2-Cyclohexyl-propionic acid(3527-63-7)

Safety Data

• Hazardous Substances Data: 3527-63-7(Hazardous Substances Data)

Usage

General Description

(S)-2-Cyclohexyl-propionic acid, also known as ibuprofen, is a nonsteroidal anti-inflammatory drug (NSAID) that is commonly used for its analgesic, anti-inflammatory, and antipyretic properties. It works by inhibiting the production of prostaglandins, which are chemicals that cause pain and inflammation in the body. Ibuprofen is widely used to alleviate pain and reduce fever, and it is often prescribed for conditions such as arthritis, menstrual cramps, and mild to moderate pain. However, it also has potential side effects, such as stomach irritation, gastrointestinal bleeding, and an increased risk of cardiovascular events, especially with prolonged use or at high doses. It is important to use ibuprofen cautiously and under the guidance of a healthcare professional to minimize the risk of adverse effects.

Upstream product

• 13865-50-4 methoxymethyl phenyl sulfide 
• 181268-49-5 S-Phenyl-S-((E)-1-trimethylsilyl-2-cyclohexylethenyl)-N-(toluene-p-sulfonyl)sulfoximine 
• 62393-68-4 (2S)-(+)-2-cyclohexyl-1-propanal 
• 7782-24-3 (S)-2-Phenylpropionic acid 

Downstream Products

• 74609-12-4 (2R,4S,5R,6S)-6-Cyclohexyl-5-hydroxy-4-methyl-2-phenyl-2-trimethylsilanyloxy-heptan-3-one 
• 74609-16-8 (2R,4R,5S,6S)-6-Cyclohexyl-5-hydroxy-4-methyl-2-phenyl-2-trimethylsilanyloxy-heptan-3-one 
• 74562-55-3 (2S,4S,5R,6S)-6-Cyclohexyl-5-hydroxy-4-methyl-2-phenyl-2-trimethylsilanyloxy-heptan-3-one 
• 74609-15-7 (2S,4R,5S,6S)-6-Cyclohexyl-5-hydroxy-4-methyl-2-phenyl-2-trimethylsilanyloxy-heptan-3-one 
• 74562-56-4 (4S,5R,6S)-6-Cyclohexyl-5-hydroxy-2,4-dimethyl-2-trimethylsilanyloxy-heptan-3-one 
• 74609-17-9 (4R,5S,6S)-6-Cyclohexyl-5-hydroxy-2,4-dimethyl-2-trimethylsilanyloxy-heptan-3-one 
• 62393-68-4 (2S)-(+)-2-cyclohexyl-1-propanal 
• 5442-00-2 (S)-2-cyclohexylpropan-1-ol 
• 2511-00-4 ethyl (S)-2-cyclohexylpropanoate 

Relevant articles and documents

COMPOUNDS USEFUL AS MODULATORS OF TRPM8

The present invention includes compounds useful as modulators of TRPM8, such as compounds of Formulae (Ia), (Ib) and (Ic), and the subgenus and species thereof; personal products containing those compounds; and the use of those compounds and the personal products, particularly the use of increasing or inducing chemesthetic sensations, such as cooling or cold sensations.

Chiral Synthesis via Organoboranes. 30. Facile Synthesis, by the Matteson Asymmetric Homologation Procedure, of α-Methyl Boronic Acids Not Available from Asymmetric Hydroboration and Their Conversion into the Corresponding Aldehydes, Ketones, Carboxylic Acids, and Amines of High Enan...

2-(α-Methylalkyl)- or 2-(α-arylethyl)-1,3,2-dioxaborinanes, RMeHC*BO2(CH2)3 (R = alkyl or aryl), of very high enantiomeric purity, not available from asymmetric hydroboration, can be prepared by the Matteson asymmetric homologation procedure of optically pure pinanediol or 2,3-butanediol boronate esters with (dichloromethyl)lithium, LiCHCl2, conveniently generated in situ in THF at -78 deg C, followed by reaction with either a Grignard reagent or an alkyllithium, with subsequent removal of the chiral auxiliaries. α-Methyl boronic esters thus obtained are readily converted into the corresponding aldehydes by the reaction with lithium (MPML) and mercuric chloride, followed by oxidation with hydrogen peroxide in a pH 8 buffer medium.The two-phase aqueous chromic acid procedure can be used to oxidize these aldehydes to the corresponding α-methyl carboxylic acids of very high enantiomeric purity without significant racemization.Additionally, pinanediol or 2,3-butanediol α-methylorganylboronate esters can be conveniently converted into borinic ester derivatives, RMeHC*BMe(OMe), of very high enantiomeric purity by reaction with methyllithium, followed by treatment with methanolic hydrogen chloride and subsequent recovery of the valuable chiral auxiliaries.These borinic ester derivatives are converted into α-methyl ketones and α-methyl primary amines of known absolute configuration by the α,α-dichloromethyl methyl ether (DCME) reaction and the reaction with hydroxylamine-O-sulfonic acid, respectively.The present synthesis of chiral 2-organyl-1,3,2-dioxaborinanes by the Matteson route, together with our direct asymmetric hydroboration procedure, makes it possible to synthesize many chiral boronic acid derivatives in very high enantiomeric purities.These complementary procedures greatly expand the scope of asymmetric synthesis via chiral organoboranes.