3528-50-5

Basic information

• Product Name: 1-cyclohexyl-1H-pyrazol-5-amine
• Synonyms: 1H-pyrazol-5-amine, 1-cyclohexyl-;(2-cyclohexylpyrazol-3-yl)amine;2-cyclohexylpyrazol-3-amine;1-cyclohexyl-1H-pyrazol-5-amine(SALTDATA: FREE);2-cyclohexyl-3-pyrazolamine
• CAS NO: 3528-50-5
• Molecular Formula: C₉H₁₅N₃
• Molecular Weight: 165.24
• EINECS: 222-549-7
• Mol File: 3528-50-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 329°C at 760 mmHg
• Flash Point: 152.8°C
• Appearance: /
• Density: 1.24g/cm³
• Vapor Pressure: 0.000183mmHg at 25°C
• Refractive Index: 1.641
• CAS DataBase Reference: 1-cyclohexyl-1H-pyrazol-5-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-cyclohexyl-1H-pyrazol-5-amine(3528-50-5)
• EPA Substance Registry System: 1-cyclohexyl-1H-pyrazol-5-amine(3528-50-5)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• HazardClass: IRRITANT
• Hazardous Substances Data: 3528-50-5(Hazardous Substances Data)

Usage

General Description

1-Cyclohexyl-1H-pyrazol-5-amine is a chemical compound with the molecular formula C10H16N2. It is a member of the pyrazole class of compounds and consists of a cyclohexyl group attached to a pyrazole ring with an amine group at the 5th position. 1-Cyclohexyl-1H-pyrazol-5-amine has potential applications in the pharmaceutical industry, particularly in the development of new drugs and therapeutic agents. It may also have uses in chemical research and as a building block for the synthesis of other organic compounds. Additionally, it is important to handle this chemical with care and follow proper safety protocols, as it may have certain hazards associated with its handling and use.

InChI:InChI=1/C9H15N3/c10-9-6-7-11-12(9)8-4-2-1-3-5-8/h6-8H,1-5,10H2

Upstream product

• 21253-62-3 ethyl 5-amino-1-cyclohexyl-1H-pyrazole-4-carboxylate 
• 6498-34-6 cyclohexylhydrazine 
• 137968-13-9 1-(Cyclohexylideneamino)pyrazole 
• 108-94-1 cyclohexanone 
• 137968-20-8 1-(Cyclohexylamino)pyrazole 

Relevant articles and documents

The optimization and characterization of functionalized sulfonamides derived from sulfaphenazole against Mycobacterium tuberculosis with reduced CYP 2C9 inhibition

In this study, a series of sulfonamide compounds was designed and synthesized through the systematic optimization of the antibacterial agent sulfaphenazole for the treatment of Mycobacterium tuberculosis (M. tuberculosis). Preliminary results indicate that the 4-aminobenzenesulfonamide moiety plays a key role in maintaining antimycobacterial activity. Compounds 10c, 10d, 10f and 10i through the optimization on phenyl ring at the R2 site on the pyrazole displayed promising antimycobacterial activity paired with low cytotoxicity. In particular, compound 10d displayed good activity (MIC = 5.69 μg/mL) with low inhibition of CYP 2C9 (IC50 > 10 μM), consequently low potential risk of drug-drug interaction. These promising results provide new insight into the combination regimen using sulfonamide as one component for the treatment of M. tuberculosis.

A novel dehydrogenation occurring during the synthesis of the new heterocyclic system 1H pyrazolo[3,4 b][2,7]naphthyridin 8 one

-