3528-51-6

Basic information

• Product Name: 1-benzyl-1H-pyrazol-5-amine
• Synonyms: [2-(benzyl)pyrazol-3-yl]amine;2-(phenylmethyl)pyrazol-3-amine;1-benzyl-1H-pyrazol-5-amine(SALTDATA: FREE);2-(phenylMethyl)pyrazol-3-aMine[2-(benzyl)pyrazol-3-yl]aMine;1-(phenylmethyl)-1H-Pyrazol-5-amine;1-bezyl-1H-pyrazol-5-amine
• CAS NO: 3528-51-6
• Molecular Formula: C10H11N3
• Molecular Weight: 173.22
• EINECS: 222-550-2
• Mol File: 3528-51-6.mol
• Article Data: 11

Chemical Properties

• Melting Point: 79-81 °C
• Boiling Point: 369.4 °C at 760 mmHg
• Flash Point: 177.2 °C
• Appearance: /
• Density: 1.16 g/cm³
• Vapor Pressure: 1.19E-05mmHg at 25°C
• Refractive Index: 1.622
• Storage Temp.: 2-8°C
• PKA: 3.92±0.10(Predicted)
• CAS DataBase Reference: 1-benzyl-1H-pyrazol-5-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-1H-pyrazol-5-amine(3528-51-6)
• EPA Substance Registry System: 1-benzyl-1H-pyrazol-5-amine(3528-51-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 3528-51-6(Hazardous Substances Data)

Usage

General Description

1-Benzyl-1H-pyrazol-5-amine is a chemical compound with the molecular formula C11H12N4. It is a pyrazole derivative with a benzyl group attached to the nitrogen atom. 1-benzyl-1H-pyrazol-5-amine is commonly used as a building block in organic synthesis to create a variety of other compounds. It has potential applications in pharmaceutical research and drug development, as well as in the synthesis of agrochemicals and other specialty chemicals. Its unique structure and reactivity make it a valuable tool for creating new molecules with specific properties for a range of applications.

InChI:InChI=1/C10H11N3/c11-10-6-7-12-13(10)8-9-4-2-1-3-5-9/h1-7H,8,11H2

Upstream product

• 6162-76-1 cyanoacetaldehyde 
• 555-96-4 Benzylhydrazine 
• 100-52-7 benzaldehyde 
• 107-13-1 acrylonitrile 
• 1202-58-0 (2-cyanoethyl)hydrazone of benzaldehyde 
• 137968-21-9 1-(Benzylamino)pyrazole 
• 871-29-4 trans-β-chloroacrylonitrile 

Downstream Products

• 37801-55-1 1-benzyl-4-chloro-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester 
• 1370535-29-7 C₁₀H₁₁BN₂O₂ 
• 73498-43-8 1-Benzyl-6,7-dihydro-4-methyl-6-oxo-pyrazolo<3,4-b>pyridin 
• 1609938-62-6 1-benzyl-5-iodo-1H-pyrazole 
• 1340592-21-3 C₂₁H₁₆FN₃O₂ 
• 1340592-22-4 [1-benzyl-4-(4-fluoro-2-methyl-phenyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-methyl-amine 
• 1340592-20-2 [1-Benzyl-4-(4-fluoro-2-methyl-phenyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-carbamic acid tert-butyl ester 
• 1340592-19-9 1-benzyl-4-(4-fluoro-2-methyl-phenyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester 
• 1340591-83-4 N-[1-benzyl-4-(4-fluoro-2-methyl-phenyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-2-(3,5-bis-trifluoromethyl-phenyl)-N-methyl-isobutyramide 
• 949321-55-5 C₁₇H₁₇N₅O₂ 
• 1002742-47-3 1-benzyl-4,6-bis(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidine 
• 75427-17-7 1-(4-nitrobenzyl)-1H-pyrazolo<3,4-b>pyridine 7-oxide 
• 75427-16-6 1-benzyl-5-acetoxy-1H-pyrazolo<3,4-b>pyridine 
• 75427-18-8 1-(4-nitrobenzyl)-1H-pyrazolo<3,4-b>pyridine 

Relevant articles and documents

Synthesis of 2-benzyl-2H-pyrazole-3,4-diamine dihydrochloride

This report describes a straightforward, high yield synthesis of a previously inaccessible N-protected diaminopyrazole in five steps starting from acrylonitrile, hydrazine and benzaldehyde.

TRIAZOLOPYRIDAZINE

The present invention encompasses compounds of general formula (I), wherein the groups R1 to R3 have the meanings given in the claims and in the specification. The compounds of the invention are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation pharmaceutical preparations containing such compounds and their uses as a medicament.

TETRAZOLE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS

The invention relates to tetrazole compounds of formula (I) wherein X, Y, Z, R1, R2 and R3 are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds use as medicaments, especially as orexin receptor antagonists.