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35285-69-9

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35285-69-9 Usage

Chemical Properties

Different sources of media describe the Chemical Properties of 35285-69-9 differently. You can refer to the following data:
1. White or almost white, hygroscopic, crystalline powder.
2. Propylparaben sodium occurs as a white, crystalline, odorless or almost odorless powder.

Uses

Different sources of media describe the Uses of 35285-69-9 differently. You can refer to the following data:
1. Pharmaceutic aid (antimicrobial preservative).
2. Sodium Propylparaben is a preservative. Sodium Propylparaben is also an excipient used in various pharmaceutical formulations.

Production Methods

Propylparaben sodium is produced from benzoic acid.

Flammability and Explosibility

Notclassified

Pharmaceutical Applications

Propylparaben sodium is used as an antimicrobial or antifungal preservative in oral pharmaceuticals and in many water-based cosmetics. It is generally used in combination with other paraben esters.

Contact allergens

This substance is one of the parabens family. Parabens are esters formed by p-hydroxybenzoic acid and an alcohol. They are largely used as biocides in cosmetics and toiletries, medicaments, or food. They have synergistic power with other biocides. Parabens can induce allergic contact dermatitis, mainly in chronic dermatitis and wounded skin.

Safety

Propylparaben sodium is used in oral pharmaceuticals and cosmetics. The pure form is toxic by the IV route and moderately toxic by ingestion and the IP route. Propylparaben sodium may cause asthma, rashes, and hyperactivity. LD50 (mouse, IP): 0.49 g/kg LD50 (mouse, IV): 0.18 g/kg LD50 (mouse, oral): 3.7 g/kg

storage

Propylparaben sodium is stable under normal conditions. It decomposes on heating. Store in a tightly closed container.

Incompatibilities

The activity of propylparaben sodium can be adversely affected by the presence of other excipients or active ingredients, such as atropine, essential oils, iron, magnesium trisilicate, talc, polysorbate 80 and other nonionic surfactants, sorbitol, weak alkalis, and strong acids.

Regulatory Status

Included in the FDA Inactive Ingredients Database (oral capsules, tablets, suspensions). Accepted for use as a food additive in Europe. Included in nonparenteral medicines (oral capsules, mixtures, orodispersible tablets, solutions and suspensions; cutaneous emulsions) licensed in the UK.

Check Digit Verification of cas no

The CAS Registry Mumber 35285-69-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,5,2,8 and 5 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 35285-69:
(7*3)+(6*5)+(5*2)+(4*8)+(3*5)+(2*6)+(1*9)=129
129 % 10 = 9
So 35285-69-9 is a valid CAS Registry Number.
InChI:InChI=1/C10H12O3.Na/c1-2-7-13-10(12)8-3-5-9(11)6-4-8;/h3-6,11H,2,7H2,1H3;/q;+1/p-1

35285-69-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name sodium,4-propoxycarbonylphenolate

1.2 Other means of identification

Product number -
Other names Sodium Propylparaben

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:35285-69-9 SDS

35285-69-9Synthetic route

nipasol
94-13-3

nipasol

sodium propyl paraben
35285-69-9

sodium propyl paraben

Conditions
ConditionsYield
With sodium hydride In diethylene glycol dimethyl ether Product distribution / selectivity;
sodium propyl paraben
35285-69-9

sodium propyl paraben

sorbinyl chloride
2614-88-2

sorbinyl chloride

4-((2E,4E)-Hexa-2,4-dienoyloxy)-benzoic acid propyl ester
88973-91-5

4-((2E,4E)-Hexa-2,4-dienoyloxy)-benzoic acid propyl ester

Conditions
ConditionsYield
85%
1-(2-hydroxyethyl)-2-pyrrolidinone
3445-11-2

1-(2-hydroxyethyl)-2-pyrrolidinone

polydichlorophosphazene

polydichlorophosphazene

sodium propyl paraben
35285-69-9

sodium propyl paraben

poly{[2-(2-oxo-1-pyrrolidinyl)ethoxy](4-carboxylatophenoxy)phosphazene}

poly{[2-(2-oxo-1-pyrrolidinyl)ethoxy](4-carboxylatophenoxy)phosphazene}

Conditions
ConditionsYield
Stage #1: 1-(2-hydroxyethyl)-2-pyrrolidinone With sodium hydride In 1,4-dioxane
Stage #2: sodium propyl paraben In 1,4-dioxane; diethylene glycol dimethyl ether at 20℃;
Stage #3: polydichlorophosphazene With potassium hydroxide; water more than 3 stages;
75%
polydichlorophosphazene

polydichlorophosphazene

sodium 1-(2-hydroxyethyl)-2-pyrrolidone
866641-89-6

sodium 1-(2-hydroxyethyl)-2-pyrrolidone

sodium propyl paraben
35285-69-9

sodium propyl paraben

poly{[2-(2-oxo-1-pyrrolidinyl)ethoxy](4-carboxylatophenoxy)phosphazene}

poly{[2-(2-oxo-1-pyrrolidinyl)ethoxy](4-carboxylatophenoxy)phosphazene}

Conditions
ConditionsYield
Stage #1: polydichlorophosphazene; sodium propyl paraben In diethylene glycol dimethyl ether at 50 - 100℃; for 3h;
Stage #2: sodium 1-(2-hydroxyethyl)-2-pyrrolidone In 1,4-dioxane; diethylene glycol dimethyl ether at 50℃; for 20h;
Stage #3: With hydrogenchloride; potassium hydroxide; water; ammonium bicarbonate more than 3 stages;
38.6%
nipasol
94-13-3

nipasol

sodium propyl paraben
35285-69-9

sodium propyl paraben

poly[di(4-propoxycarbonylphenoxy)phosphazene]; monomer(s): sodium propyl paraben; propyl 4-hydroxybenzoate

poly[di(4-propoxycarbonylphenoxy)phosphazene]; monomer(s): sodium propyl paraben; propyl 4-hydroxybenzoate

Conditions
ConditionsYield
With poly(dichlorophosphazene) In diethylene glycol dimethyl ether for 8h; Heating;

35285-69-9Upstream product

35285-69-9Relevant articles and documents

Biodegradable polyphosphazenes containing pyrrolidone side groups

-

Page/Page column 4; 5, (2008/12/06)

Biodegradable polyphosphazene polymers containing pyrrolidone side groups, and the biomedical use of such polyphosphazene polymers are disclosed.

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