353-54-8Relevant articles and documents
Gram Scale Synthesis of Honokiol
Kumar, Y. Bharath,Srihari, P.,Suresh, B.
, (2021/11/12)
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Concise and practical approach for the synthesis of honokiol, a neurotrophic agent
Khan, P. Rasvan,Mujawar, Taufiqueahmed,Shankar, G.,Shekhar, P.,Subba Reddy, BV.,Subramanyam, Ravi
supporting information, (2020/08/06)
An improved method has been developed for the synthesis of honokiol using a readily available p-bromophenol as a precursor. The key step involved in this method is ortho-lithiation facilitated by methoxymethyl ether (MOM). Other important steps are ortho-allyl phenyl ether Claisen rearrangement and a Suzuki coupling for the construction of biaryls. This method does not require pre-functionalization of aromatic ring with bromide for the generation of arylboronic acid.
SYNTHESIS OF HONOKIOL
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, (2017/06/01)
Disclosed herein are improved methods for the synthesis of honokiol, as well as methods for the synthesis of 3,3′-di-tert-butyl-5,5′-dimethyl-[1,1′-biphenyl]-2,4′-diol, 3′,5-dimethyl-[1,1′-biphenyl]-2,4′-diol, and 2,4′-dimethoxy-3′,5-dimethyl-1,1′-biphenyl, 3,3′,5,5′-tetra-tert-butyl-[1,1′-biphenyl]-2,4′-diol, and certain tetrasubstituted bisphenols, and uses therefor.