35308-68-0

Basic information

• Product Name: 1,5,6,7-TETRAHYDRO-2-METHYL-4H-INDOL-4-ONE
• Synonyms: 1,5,6,7-TETRAHYDRO-2-METHYL-4H-INDOL-4-ONE;2-METHYL-4-OXO-4,5,6,7-TETRAHYDROINDOLE;1,5,6,7-TETRAHYDRO-2-METHYL-4H-INDOL-4-ONE 98.0+%(GC);2-Methyl-4,5,6,7-tetrahydro-1H-indol-4-one;4-Oxo-2-Methyl-4,5,6,7-tetrahydroindole;4,5,6,7-Tetrahydro-2-methyl-1H-indole-4-one;1,5,6,7-Tetrahydro-2-methyl-4H-indol-4-one
• CAS NO: 35308-68-0
• Molecular Formula: C₉H₁₁NO
• Molecular Weight: 149.19
• Product Categories: Heterocycle-Indole series
• Mol File: 35308-68-0.mol
• Article Data: 18

Chemical Properties

• Melting Point: 204 °C
• Boiling Point: 330.314 °C at 760 mmHg
• Flash Point: 161.582°C
• Appearance: /
• Density: 1.171 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.581
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• CAS DataBase Reference: 1,5,6,7-TETRAHYDRO-2-METHYL-4H-INDOL-4-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,5,6,7-TETRAHYDRO-2-METHYL-4H-INDOL-4-ONE(35308-68-0)
• EPA Substance Registry System: 1,5,6,7-TETRAHYDRO-2-METHYL-4H-INDOL-4-ONE(35308-68-0)

Safety Data

• Hazardous Substances Data: 35308-68-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H11NO/c1-6-5-7-8(10-6)3-2-4-9(7)11/h5,10H,2-4H2,1H3

Upstream product

• 52035-11-7 N-<(3-oxo-2-cyclohexenyl)imino>triphenylphosphorane 
• 598-31-2 1-bromoacetone 
• 504-02-9 1,3-cylohexanedione 
• 78-95-5 chloroacetone 
• 2749-11-3 (S)-Alaninol 
• 36625-33-9 3-azido-2-cyclohexen-1-one 
• 82544-29-4 3-amino-2-<2-oxofuran-5(H)-yl>-2-cyclohexene-1-one 
• 90534-62-6 2-(2-oxopropyl)cyclohexane-1,3-dione 
• 82537-40-4 4,5,6,7-tetrahydro-4-oxo-1H-indole-2-acetic acid 
• 134256-35-2 2-(2-Bromo-allyl)-3-chloro-cyclohex-2-enone 
• 458530-50-2 1-(3-dimethoxypropyl-2-yl)amino-3-cyclohexenone 
• 95526-46-8 3-hydroxy-2-(2-oxopropyl)-2-cyclohexen-1-one 
• 73336-28-4 2-(2-bromoprop-2-en-1-yl)cyclohexane-1,3-dione 

Downstream Products

• 95526-50-4 1,5,6,7-Tetrahydro-2-methyl-1-tosyl-4H-indol-4one 
• 1092522-06-9 2-methyl-1-(phenylsulfonyl)-1,5,6,7-tetrahydro-4H-indol-4-one 
• 6116-76-3 3-ethyl-2-methyl-4-oxo-1H-4,5,6,7-tetrahydroindole 
• 1260673-40-2 3-(4-chlorophenylsulfanyl)-2-methyl-4,5,6,7-tetrahydro-1H-indol-4-one 
• 1260673-41-3 N-[3-(4-chlorophenylsulfanyl)-2-methyl-4,5,6,7-tetrahydro-1H-indol-4-ylidene]hydroxylamine 
• 1219450-68-6 3-(hydroxy(2-(pyrrolidin-1-ylsulfonyl)phenyl)methyl)-2-methyl-6,7-dihydro-1H-indol-4(5H)-one 

Relevant articles and documents

Catalytic Acceptorless Dehydrogenation of Amino Alcohols and 2-Hydroxybenzyl Alcohols for Annulation Reaction under Neutral Conditions

A base-free and acceptorless Ru-catalyzed dehydrogenative approach has been developed for the synthesis ofN-heterocycles by using 1,3-dicarbonyls and amino alcohols through a domino sequential enamine formation and intramolecular oxidative cyclization strategy. This unified approach is also applicable for the synthesis of O-heterocycles involving 2-hydroxybenzyl alcohol as a coupling reactant via consecutive C-alkylation and intramolecular cyclization steps. The present protocol is general for the synthesis of varieties of biologically important scaffolds, such as tetrahydro-4H-indol-4-one, 3,4-dihydroacridin-1(2H)-one, and tetrahydro-1H-xanthen-1-ones derivatives using a single catalytic system, viz. RuH2CO(PPh3)3. Environmentally benign H2O and H2are the only byproducts in this domino process. Moreover, RuH2CO(PPh3)3-catalyzed C3-alkylation of tetrahydro-4H-indol-4-one using alcohol as a alkylating partner is also described in this report. For the first time, a solvent-free gram-scale reaction for the acceptorless dehydrogenative annulation has been demonstrated. A plausible mechanism for the Ru-catalyzed base-free and acceptorless dehydrogenative annulation of amino alcohols or 2-hydroxybenzyl alcohols has been provided with several experimental investigations and spectroscopic evidence.

Urea decomposition: Efficient synthesis of pyrroles using the deep eutectic solvent choline chloride/urea

A simple and efficient method is reported for the synthesis of pyrroles via condensation of a series of tricarbonyl compounds with ammonia, which was generated in situ from decomposition of the deep eutectic solvent choline chloride/urea.

HYDROXAMATE DERIVATIVES FOR HDAC INHIBITOR, AND THE PHARMACEUTICAL COMPOSITION COMPRISING THEREOF

The present invention relates to a novel hydroxamate derivatives, more specifically, to novel hydroxamate derivatives having inhibitory activity against Histone Deacetylase (HDAC), isomers thereof, pharmaceutically acceptable salts thereof, hydrates or solvates thereof, use for preparing pharmaceutical compositions, pharmaceutical compositions comprising the same, treatment method using said composition, and a preparing method of novel hydroxamate derivatives. The novel selective hydroxamate derivatives having inhibitory activity against Histone Deacetylase (HDAC) compositions can be used for treatment of inflammatory disease, rheumatoid arthritis, or degenerative disease.