3535-37-3Relevant articles and documents
Synthesis and antitumor activity of novel pyridoxine-based structural analogs of saccharumoside-B
Pugachev, Mikhail V.,Agafonova, Maria N.,Bastrikova, Oksana A.,Gnezdilov, Oleg I.,Nikishova, Tatyana V.,Balakin, Konstantin V.,Shtyrlin, Yurii G.
, p. 1139 - 1150 (2021/03/31)
A series of 11 new pyridoxine-based structural analogs of saccharumoside-B were obtained using original synthetic approach. Antitumor activity of these compounds against nine human tumor cell lines (MCF-7, MDA-MB-231, A-498, SNB-19, M-14, NCI-H322M, HCT-115, HCT-116, and PC-3) was studied, and cytotoxic activity to three normal (HEK-293, Chang Liver, and MSC) cell lines was evaluated. Among the synthesized compounds, 12d, 12e, 13b, 13d, 13e, and 14 exhibited the highest antitumor activity, comparable to that of camptothecin and doxorubicin, but with significantly increased selectivity toward tumor cells. [Figure not available: see fulltext.]
Synthesis of N -(Hetero)arylconvolvine Derivatives through a Palladium-Catalyzed Buchwald-Hartwig Cross-Coupling
Alami, Mouad,Ghermani, Noureddine,Hassine, Manel,Jannet, Hichem Ben,Messaoudi, Samir
, p. 450 - 458 (2020/01/23)
The present study describes the isolation of convolvine from the roots of the Tunisian plant Convolvulus dorycnium L. and its synthesis through a four-step sequence starting from tropine. Then, an efficient synthesis of N -(het)aryltropanes derivatives by
Preparation method of 3,4-dimethoxybenzoyl chloride
-
Paragraph 0007-0010, (2018/12/03)
The invention discloses a preparation method of 3,4-dimethoxybenzoyl chloride and belongs to the technical field of medicine techniques. The technical problem to be solved by the invention is to relate to a more advanced preparation method of 3,4-dimethox