35374-43-7

Basic information

• Product Name: 2-[(2-chloroethyl)sulfanyl]naphthalene
• Synonyms: Naphthalene, 2-[(2-chloroethyl)thio]-
• CAS NO: 35374-43-7
• Molecular Formula: C₁₂H₁₁ClS
• Molecular Weight: 222.7337
• Mol File: 35374-43-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 354.7°C at 760 mmHg
• Flash Point: 158.3°C
• Density: 1.21g/cm³
• Vapor Pressure: 6.71E-05mmHg at 25°C
• Refractive Index: 1.647
• CAS DataBase Reference: 2-[(2-chloroethyl)sulfanyl]naphthalene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(2-chloroethyl)sulfanyl]naphthalene(35374-43-7)
• EPA Substance Registry System: 2-[(2-chloroethyl)sulfanyl]naphthalene(35374-43-7)

Safety Data

• Hazardous Substances Data: 35374-43-7(Hazardous Substances Data)

Usage

Structure

A naphthalene ring with a thioether functional group (-S-) and a chloroethyl substituent (-CH2CH2Cl) attached to it.

Uses

Primarily used as an intermediate in the synthesis of other organic compounds, such as pharmaceuticals, agrochemicals, and dyes.

Hazards

Known to have cytotoxic and mutagenic properties, which can be harmful to human health and the environment.

Handling and disposal

Proper handling and disposal procedures should be followed to minimize the risks associated with the chemical.

Upstream product

• 107-06-2 1,2-dichloro-ethane 
• 91-60-1 2-Naphthalenethiol 
• 17225-95-5 2-(2-naphthylthio)ethanol 

Downstream Products

• 90395-98-5 β-naphthyl 2-chloroethyl sulfone 
• 1207324-81-9 2-(2-chloroethylsulfinyl)naphthalene 

Relevant articles and documents

Divergent electrolysis for the controllable coupling of thiols with 1,2-dichloroethane: A mild approach to sulfide and sulfoxide

Organosulfurs are important commodity chemicals and indispensable synthetic intermediates in modern chemistry that were traditionally synthesized using metal catalysts, oxidants or strong bases, which caused numerous environmental pollution issues. The divergent synthesis of these scaffolds via a single catalysis under catalyst and oxidant free conditions is a fantastic idea to overcome these drawbacks. Here, we report a safe, practical and eco-friendly electrochemical methodology for the controllable dechloro-coupling of 1,2-dichloroethane (DCE) with thiols, providing value-added β-chloroethylsulfurs, which serve as versatile building blocks in the efficient late-stage conversion to bioactive molecules. The mildness and practicality of this protocol was further demonstrated by the total synthesis of anti-gout drug sulfinpyrazone in a 32% total yield over three steps.