35392-60-0

Basic information

• Product Name: 4-PHENYL-PHTHALAZINE-1-THIOL
• Synonyms: 4-Phenyl-1-phthalazinethiol;4-Phenylphthalazine-1(2H)-thione;4-phenyl-2H-phthalazine-1-thione
• CAS NO: 35392-60-0
• Molecular Formula: C₁₄H₁₀N₂S
• Molecular Weight: 238.06
• Mol File: 35392-60-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 403.4 °C at 760 mmHg
• Flash Point: 197.8 °C
• Appearance: /
• Density: 1.25g/cm³
• Vapor Pressure: 1.02E-06mmHg at 25°C
• Refractive Index: 1.69
• CAS DataBase Reference: 4-PHENYL-PHTHALAZINE-1-THIOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PHENYL-PHTHALAZINE-1-THIOL(35392-60-0)
• EPA Substance Registry System: 4-PHENYL-PHTHALAZINE-1-THIOL(35392-60-0)

Safety Data

• Hazardous Substances Data: 35392-60-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C14H10N2S/c17-14-12-9-5-4-8-11(12)13(15-16-14)10-6-2-1-3-7-10/h1-9H,(H,16,17)

Upstream product

• 5004-45-5 4-phenyl-2H-phthalazin-1-one 
• 10132-01-1 1-chloro-4-phenyl-phthalazine 
• 1875-48-5 N-aminophthalamide 
• 71-43-2 benzene 
• 19172-47-5 Lawessons reagent 
• 5004-45-5 1-hydroxy-4-phenylphthalazine 
• 108-20-3 di-isopropyl ether 

Downstream Products

• 101794-32-5 1-butylmercapto-4-phenyl-phthalazine 
• 101351-71-7 1-ethylmercapto-4-phenyl-phthalazine 
• 100881-26-3 1-methylsulfanyl-4-phenyl-phthalazine 
• 130029-28-6 8,8,9-Trimethyl-4-phenyl-8,9-dihydrothiopyrano<4,3,2-ij>phthalazine 
• 15994-75-9 1-methanesulfonyl-4-phenyl-phthalazine 
• 101350-91-8 1-ethanesulfonyl-4-phenyl-phthalazine 
• 101793-32-2 1-(butane-1-sulfonyl)-4-phenyl-phthalazine 
• 475660-39-0 1-(2-Propenylthio)-4-Phenylphthalazine 
• 125706-87-8 2-(4-phenylphthalazin-1-yl)hydrazinecarbothioamide 
• 76972-82-2 N'-(4-phenylphthalazin-1-yl)benzhydrazide 
• 86427-78-3 1-hydrazinyl-4-phenylphthalazine 
• 1250830-70-6 1-phenyl-4-[2-(pyridin-2-yl)hydrazinyl]phthalazine 
• 475660-42-5 1-(3-Chlorobenzylthio)-4-Phenylphthalazine 
• 475660-36-7 1-Benzylthio-4-phenylphthalazine 

Relevant articles and documents

A novel method for heterocyclic amide-thioamide transformations

In this paper, we introduce a novel and convenient method for the transformation of heterocyclic amides into heteocyclic thioamides. A two-step approach was applied for this transformation: Firstly, we applied a chlorination of the heterocyclic amides to afford the corresponding chloroheterocycles. Secondly, the chloroherocycles and N-cyclohexyl dithiocarbamate cyclohexylammonium salt were heated in chloroform for 12 h at 61°C to afford heteocyclic thioamides in excellent yields.

[4,5]-fused-3,6-disubstituted-pyridazines with sulfur-containing substituents in position three for the treatment of neoplasia

[4,5]-Fused-3,6 disubstituted-pydidazines of Formula I are useful for inducing or promoting apoptosis and for arresting uncontrolled neoplastic cell proliferation, and are specifically useful in the arresting and treatment of neoplasia: wherein Y1and Y2are independently selected from the group consisting of (CH2)n,—C(X)—NH—,—(CH2)n—C(X)—O—, and X is O or S; R1is selected from the group consisting of lower alkyl, lower alkenyl, lower alkynyl, and substituted or unsubstituted phenyl, pyridinyl, and the like; R2is selected from the group consisting of substituted or unsubstituted phenyl, benzyl, pyridinyl, and the like; “A” is a benzene ring fused with the pyridazine ring; and R3is independently selected in each instance form the group consisting of halogen, lower alkyl, and the like.