354-03-0

Basic information

• Product Name: BROMOCHLOROFLUOROACETIC ACID
• Synonyms: BROMOCHLOROFLUOROACETIC ACID
• CAS NO: 354-03-0
• Molecular Formula: C2HBrClFO2
• Molecular Weight: 191.38
• Mol File: 354-03-0.mol
• Article Data: 3

Chemical Properties

• Melting Point: -5°C
• Boiling Point: 181°C
• Flash Point: 58.2°C
• Appearance: /
• Density: 2.219g/cm³
• Vapor Pressure: 0.641mmHg at 25°C
• Refractive Index: 1.505
• PKA: 0.35±0.10(Predicted)
• CAS DataBase Reference: BROMOCHLOROFLUOROACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: BROMOCHLOROFLUOROACETIC ACID(354-03-0)
• EPA Substance Registry System: BROMOCHLOROFLUOROACETIC ACID(354-03-0)

Safety Data

• Hazard Codes: C
• HazardClass: CORROSIVE
• Hazardous Substances Data: 354-03-0(Hazardous Substances Data)

Usage

General Description

Bromochlorofluoroacetic acid is a synthetic chemical compound used primarily as a pesticide and herbicide. It is a derivative of acetic acid and contains bromine, chlorine, and fluorine atoms in its structure. This chemical is known for its ability to inhibit the growth of various plants and organisms, making it effective in agricultural and environmental applications. However, it has been found to be toxic to aquatic organisms and may pose risks to human health if not handled with proper precautions. Due to its potential environmental and health hazards, the use of bromochlorofluoroacetic acid is tightly regulated in many countries.

InChI:InChI=1/C2HBrClFO2/c3-2(4,5)1(6)7/h(H,6,7)

Upstream product

• 101385-65-3 methyl 2-bromo-2-chloro-2-fluoroacetate 
• 383-60-8 ethyl bromochlorofluoroacetate 
• 359-23-9 bromo-fluoroacetyl chloride 

Downstream Products

• 593-98-6 (+)-Bromchlorfluormethan 
• 593-98-6 (-)-Bromochlorofluoromethane 

Relevant articles and documents

Synthetic routes for a variety of halogenated (chiral) acetic acids from diethyl malonate

Chiral halomethane is the smallest stable molecule with a single asymmetric C-atom and halogenated acetic acids often serve as precursors. We focus on a synthetic route to synthesise chiral halogenated acetic acids with F, Cl, Br, and H/D isotopic substitution at the α-C-atom starting from diethyl malonate. This reactant is easily available, cheap and allows the obtainment of target acids in a few reaction steps with great versatility. Among all of the possible fully halogenated acetic acids (more than one hundred, which are, in principle, accessible by this route), there are only a small number of chiral halogenated acetic acids, which have been synthesized following the devised synthetic route.

A Facile Synthesis of Fluorochlorobromoacetic Acid

Fluorochlorobromoacetic acid was synthesized in the sequence of four steps from 1,1,2-trifluoro-2-chloroethylene in an overall yield of approximately 25percent. 1,1,2-Trifluoro-2-chloroethylene was first allowed to react with sodium methoxide to form 1,2-difluoro-1-chloro-2-methoxyethylene, which was then brominated with elemental bromine and the reaction product treated with concentrated sulfuric acid to give methyl fluorochlorobromoacetate.This compound was hydrolized with a diluted sodium hydroxide solution to fluorochlorobromoacetic acid.