354-13-2

Basic information

• Product Name: TRICHLOROACETYL FLUORIDE
• Synonyms: trichloroaceticfluoride;trichloro-acetylfluorid;TRICHLOROACETYL FLUORIDE;Acetyl fluoride, trichloro-;Brn 1754127
• CAS NO: 354-13-2
• Molecular Formula: C₂Cl₃FO
• Molecular Weight: 165.38
• Mol File: 354-13-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 66°C
• Flash Point: 39.6°C
• Appearance: /
• Density: 1.6826 (estimate)
• Vapor Pressure: 5.72mmHg at 25°C
• Refractive Index: 1.442
• CAS DataBase Reference: TRICHLOROACETYL FLUORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: TRICHLOROACETYL FLUORIDE(354-13-2)
• EPA Substance Registry System: TRICHLOROACETYL FLUORIDE(354-13-2)

Safety Data

• Statements: 14-34-36/37/38
• Safety Statements: 3/7-9-26-36/37/39-45
• RIDADR: 3265
• Hazardous Substances Data: 354-13-2(Hazardous Substances Data)

Usage

Safety Profile

Moderately toxic by inhalation.When heated to decomposition it emits toxic fumes of Fíand Clí.

InChI:InChI=1/C2Cl3FO/c3-2(4,5)1(6)7

Upstream product

• 37021-34-4 1,2,2,2-Tetrachloro-1-fluoroethyl methyl ether 
• 7297-44-1 trichloro-acetic acid-(3-hydroxy-propyl ester) 

Relevant articles and documents

Acid fluorides and 1,1-difluoroethyl methyl ethers as new organic sources of fluoride for antimony pentachloride-catalyzed halogen-exchange reactions

1,1-Difluoroethyl methyl ethers such as the commercial veterinary anesthetic methoxyflurane (2,2-dichoro-1,1-difluoroethyl methyl ether, 6) decompose in the presence of a catalytic amount of antimony pentachloride. The rate of decomposition is dependent upon the number and position of halogen atoms in the ether: a high degree of halogenation at the methyl group or at the 2-position of the ethyl group makes the ether less prone to decomposition. The decomposition products are acid fluorides and halogenated methanes. The fate of the antimony pentachloride is conversion to a fluorochloroantimony species which can be used in situ to selectively fluorinate a polychlorinated substrate. Thus, 1,2,2,2-tetrachloro-1-fluoroethyl methyl ether (1) is converted cleanly to the anesthetic compound 2,2,2-trichloro-1,1-difluoroethyl methyl ether (2) using 6 as the fluoride source, exploiting the difference in stability of 2 and 6 to the pentavalent antimony species. It is also demonstrated that the acid fluorides obtained from decomposition of the 1,1-difluoroethyl methyl ethers are fluoride sources for halex reactions.