354-69-8

Basic information

• Product Name: 1-IODO-2,2,3,3,3-PENTAFLUOROPROPANE
• Synonyms: 1,1,1,2,2-pentafluoro-3-iodo-propan;Propane, 1,1,1,2,2-pentafluoro-3-iodo-;PENTAFLUOROPROPYL IODIDE;1,1,1,2,2-PENTAFLUORO-3-IODOPROPANE;1H,1H-PENTAFLUORO-N-PROPYL IODIDE;1H,1H-PENTAFLUOROPROPYL IODIDE;1-IODO-2,2,3,3,3-PENTAFLUOROPROPANE;2,2,3,3,3-PENTAFLUOROPROPYL IODIDE
• CAS NO: 354-69-8
• Molecular Formula: C₃H₂F₅I
• Molecular Weight: 259.94
• EINECS: 206-568-8
• Mol File: 354-69-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 70-71°C
• Flash Point: 70-71°C
• Appearance: /
• Density: 2.092 g/cm³
• Vapor Pressure: 149mmHg at 25°C
• Refractive Index: 1.373
• Water Solubility: Insoluble in water.
• Sensitive: Light Sensitive
• BRN: 1700278
• CAS DataBase Reference: 1-IODO-2,2,3,3,3-PENTAFLUOROPROPANE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-IODO-2,2,3,3,3-PENTAFLUOROPROPANE(354-69-8)
• EPA Substance Registry System: 1-IODO-2,2,3,3,3-PENTAFLUOROPROPANE(354-69-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• TSCA: Yes
• Hazardous Substances Data: 354-69-8(Hazardous Substances Data)

Usage

Uses

1,1,1,2,2-Pentafluoro-3-iodopropane is used to produce 1,1,1,2,2-pentafluoro-propane by heating. It is an important raw material and intermediate used in organic synthesis, pharmaceuticals and agrochemicals.

InChI:InChI=1/C3H2F5I/c4-2(5,1-9)3(6,7)8/h1H2

Upstream product

• 565-42-4 2,2,3,3,3-pentafluoro-1-propyl 4-toluenesulfonate 

Downstream Products

• 672339-38-7 (Z)-2,3,3,3-tetrafluoro-1-iodoprop-1-ene 
• 104207-50-3 1--1H,1H-perfluoropropane 
• 76-05-1 trifluoroacetic acid 
• 1010731-91-5 C₁₁H₇F₁₁INS₂O₄ 
• 1814-88-6 1,1,1,2,2-pentafluoropropane 

Relevant articles and documents

Highly stereoselective approach to 3-fluoroalkylated (E)-hex-3-ene-1,5- diyne derivatives via an addition-elimination reaction

Palladium(0)-catalyzed Sonogashira cross-coupling reaction of 2-fluoroalkylated (Z)-2-fluoro-1-iodoethene, which is easily prepared from commercially available polyfluorinated alcohols in facile three steps, with terminal alkynes in DMF at room temperature for 24 h took place stereospecifically to give the corresponding 1-fluoroalkylated (Z)-1-fluorobut-1-en-3-yne derivatives in good to excellent yield. Thus obtained fluoroalkylated 1-fluoroenynes were effectively subjected to addition-elimination reaction with various alkynyllithiums at room temperature, leading to 3-fluoroalkylated hex-3-ene-1,5-diyne derivatives in good to high yields with an excellent E selectivity.

1-Iodo-polyfluoroalkanes from polyfluoroalkoxy trimethylsilanes and iodochloro triphenylphosphorane

Polyfluoroalkoxy trimethylsilanes R(f)CH2OSi(CH3)3 (from the alcohols R(f)CH2OH and HMDS), react with Pb3PICI (from ICI and Ph3P) eliminating (CH3)3SiCl. Pyrolysis of the residues gives Ph3PO and pure iodides R(f)CH2I.