35427-94-2

Basic information

• Product Name: N-benzylidene-N-(2-methylphenyl)amine oxide
• CAS NO: 35427-94-2
• Molecular Formula: C₁₄H₁₃NO
• Molecular Weight: 211.2591
• Mol File: 35427-94-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 370°C at 760 mmHg
• Flash Point: 173.5°C
• Density: 1.117g/cm³
• Vapor Pressure: 2.43E-05mmHg at 25°C
• Refractive Index: 1.641
• CAS DataBase Reference: N-benzylidene-N-(2-methylphenyl)amine oxide(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzylidene-N-(2-methylphenyl)amine oxide(35427-94-2)
• EPA Substance Registry System: N-benzylidene-N-(2-methylphenyl)amine oxide(35427-94-2)

Safety Data

• Hazardous Substances Data: 35427-94-2(Hazardous Substances Data)

Upstream product

• 88-72-2 1-methyl-2-nitrobenzene 
• 100-52-7 benzaldehyde 
• 611-22-3 N-(o-tolyl)hydroxylamine 

Downstream Products

• 115879-44-2 3,4-Diphenyl-2-o-tolyl-[1,2,4]oxadiazolidin-5-one 
• 115879-45-3 3-Phenyl-2,4-di-o-tolyl-[1,2,4]oxadiazolidin-5-one 
• 115879-46-4 4-Naphthalen-1-yl-3-phenyl-2-o-tolyl-[1,2,4]oxadiazolidin-5-one 
• 66625-55-6 (E)-1-methyl-2-(o-tolylimino)indolin-3-one 
• 1345509-85-4 ethyl 2,4-diphenyl-1-o-tolyl-1H-imidazole-5-carboxylate 
• 1185154-55-5 (±)-3-ethyl-7-methyl-3-phenylindolin-2-one 
• 100-52-7 benzaldehyde 
• 91075-24-0 7-Methyl-2-(trichlormethylsulfinylmethyl)indol 
• 97369-40-9 (7-Methyl-2-indolyl)-3-phenylacrylnitril 
• 1435517-47-7 (S,E)-N-(4-fluorobenzyl)-4-methyl-N-((3-phenyl-2-(o-tolyl)isoxazolidin-4-ylidene)methyl)benzenesulfonamide 

Relevant articles and documents

Synthesis of Benzimidazolones via One-Pot Reaction of Hydroxylamines, Aldehydes, and Trimethylsilyl Cyanide Promoted by Diacetoxyiodobenzene

A novel and efficient PhI(OAc)2-promoted one-pot reaction of aromatic hydroxylamines, aldehydes, and TMSCN in the presence of BF3·Et2O is described. A wide variety of N-substituted benzimidazolones are obtained with satisfactory yields under mild reaction conditions. The method was proven to be efficient for the synthesis of benzimidazolone derivatives from readily available starting materials.

An asymmetric pericyclic cascade approach to 3-alkyl-3-aryloxindoles: Generality, applications and mechanistic investigations

The reaction of L-serine derived N-arylnitrones with alkylarylketenes generates asymmetric 3-alkyl-3-aryloxindoles in good to excellent yields (up to 93%) and excellent enantioselectivity (up to 98% ee) via a pericyclic cascade process. The optimization, scope and applications of this transformation are reported, alongside further synthetic and computational investigations. The preparation of the enantiomer of a Roche anti-cancer agent (RO4999200) 1 (96% ee) in three steps demonstrates the potential utility of this methodology.

Hetero-Cope Rearrangements, III. - Vinylindoles via Hetero-Cope Rearrangement

The reaction of N-phenylnitrones 1 with allenes 2 which are substituted with electron acceptor groups gives various products via addition and sigmatropic rearrangement depending on the specific acceptor group.In this manner one obtains 2-substituted indoles 8a, 8b, and 10 from propadienyl trichloromethyl sulfoxide.Using phenyl propadienyl sulfone a derivative 4a of tetrahydro-1-benzazepin-4-one is obtained.Reactions with allenecarbonitril proceed via several steps and yield 2-vinylindoles of type 6.Intermediate products could not be isolated.