35543-25-0

Basic information

• Product Name: 1-Pyrrolidinobutyronitrile
• Synonyms: 4-(1-Pyrrolidine)butyronitrile;4-Pyrrolidinylbutanenitrile;PYRROLIDINOBUTYRONITRILE;1-PYRROLIDINOBUTYRONITRILE;1-PYRROLIDINEBUTANENITRILE;1-PYRROLIDINEBUTYRONITRILE;1-(3-CYANOPROPYL)PYRROLIDINE;4-(N-PYRROLIDINO)-BUTYRONITRILE
• CAS NO: 35543-25-0
• Molecular Formula: C₈H₁₄N₂
• Molecular Weight: 138.21
• EINECS: 252-612-4
• Mol File: 35543-25-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 115 °C18 mm Hg(lit.)
• Flash Point: 211 °F
• Appearance: Clear colorless to brown/Liquid
• Density: 0.926 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0725mmHg at 25°C
• Refractive Index: n20/D 1.46(lit.)
• PKA: 9.93±0.20(Predicted)
• CAS DataBase Reference: 1-Pyrrolidinobutyronitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Pyrrolidinobutyronitrile(35543-25-0)
• EPA Substance Registry System: 1-Pyrrolidinobutyronitrile(35543-25-0)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-37/39-36/37/39-36
• RIDADR: 3276
• WGK Germany: 3
• RTECS: UY0270000
• HazardClass: IRRITANT
• Hazardous Substances Data: 35543-25-0(Hazardous Substances Data)

Usage

Chemical Properties

clear colorless to brown liquid

InChI:InChI=1/C8H14N2/c9-5-1-2-6-10-7-3-4-8-10/h1-4,6-8H2/p+1

Upstream product

• 123-75-1 pyrrolidine 
• 628-20-6 4-Chlorobutyronitrile 

Downstream Products

• 1236131-38-6 (Z)-2-phenyl-6-(pyrrolidin-1-yl)hex-2-enenitrile 
• 244291-68-7 1-[4-(2-methylphenyl)-4-oxo-1-butyl]pyrrolidine 
• 15620-49-2 4,6-dimethyl-2-(3-pyrrolidin-1-yl-propyl)-5,6-dihydro-4H-[1,3,4]thiadiazine 
• 153906-01-5 2-(3,4-Dichloro-phenyl)-N-methyl-N-{4-[methyl-(4-pyrrolidin-1-yl-butyl)-amino]-butyl}-acetamide 
• 153905-99-8 2-(3,4-Dichloro-phenyl)-N-methyl-N-{3-[methyl-(4-pyrrolidin-1-yl-butyl)-amino]-propyl}-acetamide 

Relevant articles and documents

Copper-Catalyzed Cyanoalkylation of Amines via C-C Bond Cleavage: An Approach for C(sp3)-N Bond Formations

The efficient copper-catalyzed cyanoalkylation of amines via C-C bond cleavage has been demonstrated. Distinctive features of this procedure involves mild conditions, broad range of nitrogen nucleophiles, high selectivity, and good functional group tolerance, thus providing a useful approach for the C(sp3)-N bond formations. Most importantly, this protocol is applicable to the late-stage functionalization of natural products, amino acid esters, and drugs. Mechanistic studies suggest that a radical intermediate was involved in this transformation.

Anthelmintic 1-(substituted phenyl)-3-alkanimidoyl ureas

The compounds of this invention are novel imidoylureas having anthelmintic activity and imidoylthioureas having antifertility activity. They are prepared by the reaction of appropriate amidines with appropriate isocyanates or isothiocyanates.