355809-07-3

Basic information

• Product Name: N-benzyl-2-chloro-5-fluoropyrimidin-4-amine
• Synonyms: N-benzyl-2-chloro-5-fluoropyrimidin-4-amine
• CAS NO: 355809-07-3
• Molecular Weight: 237.664
• Mol File: 355809-07-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-benzyl-2-chloro-5-fluoropyrimidin-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-2-chloro-5-fluoropyrimidin-4-amine(355809-07-3)
• EPA Substance Registry System: N-benzyl-2-chloro-5-fluoropyrimidin-4-amine(355809-07-3)

Safety Data

• Hazardous Substances Data: 355809-07-3(Hazardous Substances Data)

Upstream product

• 2927-71-1 2,4-dichloro-5-fluoropyrimidine 
• 100-46-9 benzylamine 
• 1780-31-0 2,6-dichloro-5-methylpyrimidine 

Downstream Products

• 1044210-61-8 C₁₁H₁₂FN₅ 

Relevant articles and documents

CHEMICAL COMPOUNDS

The present disclosure describes novel compounds, or their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and their medical uses. Compounds of the disclosure have activity as dual modulators of Janus kinase (JAK), alone, or in combination with one or more of an additional mechanism, including a tyrosine kinase, such as TrkA or Syk, and PDE4, and are useful in the in the treatment or control of inflammation, auto-immune diseases, cancer, and other disorders and indications where modulation of JAK would be desirable. Also described herein are methods of treating inflammation, auto-immune diseases, cancer, and other conditions susceptible to inhibition of JAK and PDE4 by administering a compound herein described.

THERAMUTEIN MODULATORS

This invention relates to agents that are inhibitors or activators of variant forms of endogenous proteins and novel methods of identifying such variants. Of particular interest are inhibitors and activators of endogenous protein variants, encoded by genes which have mutated, which variants often arise or are at least first identified as having arisen following exposure to a chemical agent which is known to be an inhibitor or activator of the corresponding unmutated endogenous protein.