355815-47-3

Basic information

• Product Name: (4-FLUORO-BENZYL)-(4-METHOXY-BENZYL)-AMINE
• Synonyms: ART-CHEM-BB B023207;(4-FLUORO-BENZYL)-(4-METHOXY-BENZYL)-AMINE;AKOS B023207;TIMTEC-BB SBB007226;N-(4-Fluorobenzyl)-4-MethoxybenzylaMine, 97%
• CAS NO: 355815-47-3
• Molecular Formula: C₁₅H₁₆FNO
• Molecular Weight: 245.29
• Mol File: 355815-47-3.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 350.2°Cat760mmHg
• Flash Point: 165.6°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 4.45E-05mmHg at 25°C
• CAS DataBase Reference: (4-FLUORO-BENZYL)-(4-METHOXY-BENZYL)-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: (4-FLUORO-BENZYL)-(4-METHOXY-BENZYL)-AMINE(355815-47-3)
• EPA Substance Registry System: (4-FLUORO-BENZYL)-(4-METHOXY-BENZYL)-AMINE(355815-47-3)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 355815-47-3(Hazardous Substances Data)

Usage

General Description

The chemical compound (4-FLUORO-BENZYL)-(4-METHOXY-BENZYL)-AMINE is a substituted amine with a 4-fluorobenzyl and a 4-methoxybenzyl group attached to the amine nitrogen. It is commonly used in organic synthesis as a building block for the preparation of various biologically active molecules and pharmaceuticals. (4-FLUORO-BENZYL)-(4-METHOXY-BENZYL)-AMINE can be utilized as a reagent in the synthesis of complex organic compounds or as a starting material for the production of specialty chemicals. Its unique structure and reactivity make it a versatile and valuable tool for the design and synthesis of new drug candidates and other important compounds.

InChI:InChI=1/C15H16FNO/c1-18-15-8-4-13(5-9-15)11-17-10-12-2-6-14(16)7-3-12/h2-9,17H,10-11H2,1H3/p+1

Upstream product

• 105-13-5 4-Methoxybenzyl alcohol 
• 159979-96-1 4-fluorobenzyl azide 
• 1194-02-1 4-fluorobenzonitrile 
• 2393-23-9 4-methoxy-benzylamine 
• 459-57-4 4-fluorobenzaldehyde 
• 140-75-0 para-fluorobenzylamine 
• 123-11-5 4-methoxy-benzaldehyde 
• 105482-69-7 N-(4-fluorobenzyl)(4-methoxyphenyl)methanimine 

Downstream Products

• 24941-76-2 1-fluoro-4-(4-methoxyphenethyl)benzene 

Relevant articles and documents

Reductive Alkylation of Azides and Nitroarenes with Alcohols: A Selective Route to Mono- And Dialkylated Amines

Herein, we demonstrated an efficient protocol for reductive alkylation of azides/nitro compounds via a borrowing hydrogen (BH) method. By following this protocol, selective mono- and dialkylated amines were obtained under mild and solvent-free conditions. A series of control experiments and deuterium-labeling experiments were performed to understand this catalytic process. Mechanistic studies suggested that the Ir(III)-H was the active intermediate in this reaction. KIE study revealed that the breaking of the C-H bond of alcohol might be the rate-limiting step. Notably, this solvent-free strategy disclosed a high TON of around 5600. Based on kinetic studies and control experiments, a metal-ligand cooperative mechanism was proposed.

One-pot, chemoselective synthesis of secondary amines from aryl nitriles using a PdPt-Fe3O4nanoparticle catalyst

We have developed a new catalytic method for the one-pot, cascade synthesis of unsymmetrical secondary amines via the reductive amination of aryl nitriles with nitroalkanes using a PdPt-Fe3O4 nanoparticle (NP) catalyst. The use of a bimetallic catalyst resulted in enhanced reactivity and selectivity compared to that of either monometallic Pd-Fe3O4 or the Pt-Fe3O4 NP catalyst. Using this bimetallic catalytic system, we were successful in the synthesis of various unsymmetrical secondary amines under mild conditions. However, aryl nitriles containing an electron-donating substituent were rather resistant to the reductive amination, and when hexafluoroisopropanol (HFIP) was used as a co-solvent, the reaction selectivity and yield for unsymmetrical secondary amines increased dramatically. Using the catalyst system, one-pot, gram-scale synthesis of indole was possible from 2-nitrophenylacetonitrile. Due to the magnetic property of the Fe3O4 support, the bimetallic catalyst could easily be recycled using an external magnet at least four times.

Iron-Catalyzed Intramolecular C-H Amination of α-Azidyl Amides

Iron-catalyzed intramolecular C-H amination of aliphatic azides has recently emerged as a powerful tool for the preparation of nitrogen heterocycles. This paper reports that α-azidyl amides can be converted in high efficacy to imidazolinone compounds via intramolecular C(sp3)-H amination by the action of a simple catalytic system composed of FeCl2 and a β-diketiminate ligand. The reactions provide a simple and atom-economical approach toward polysubstituted imidazolinones.