35590-87-5

Basic information

• Product Name: (3S,6R)-3-(1-methylethyl)-6-(phenylmethyl)piperazine-2,5-dione
• Synonyms: (3S,6R)-3-(1-methylethyl)-6-(phenylmethyl)piperazine-2,5-dione
• CAS NO: 35590-87-5
• Molecular Weight: 246.309
• Mol File: 35590-87-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (3S,6R)-3-(1-methylethyl)-6-(phenylmethyl)piperazine-2,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (3S,6R)-3-(1-methylethyl)-6-(phenylmethyl)piperazine-2,5-dione(35590-87-5)
• EPA Substance Registry System: (3S,6R)-3-(1-methylethyl)-6-(phenylmethyl)piperazine-2,5-dione(35590-87-5)

Safety Data

• Hazardous Substances Data: 35590-87-5(Hazardous Substances Data)

Upstream product

• 145313-30-0 (R)-2-((S)-2-Amino-3-methyl-butyrylamino)-3-phenyl-propionic acid methyl ester 
• 252573-87-8 Z-Val-D-Phe-OMe 
• 946414-30-8 (3R,6S)-N⁽¹⁾-p-methoxybenzyl-3-benzyl-5-methoxy-6-iso-propyl-3,6-dihydropyrazine-2-one 

Downstream Products

• 17498-50-9 L-valine hydrochloride 
• 28069-46-7 D-phenylalanine hydrochloride 
• 4070-48-8 L-Valine methyl ester 
• 21685-51-8 D-phenylalanine methyl ester 

Relevant articles and documents

Diastereoselective synthesis of quaternary α-amino acids from diketopiperazine templates

Sequential enolate alkylations of (S)-N(1)-methyl-5-methoxy-6-isopropyl-3, 6-dihydropyrazin-2-one and (S)-N(1)-p-methoxybenzyl-5-methoxy-6-isopropyl-3,6- dihydropyrazin-2-one proceed with excellent levels of diastereoselectivity (>90% de) affording quaternary α-amino acids in high enantiomeric excess (>98% ee) after deprotection and hydrolysis. This journal is The Royal Society of Chemistry.