356-12-7 Usage
Chemical Properties
White Solid
Originator
Topsyn ,Recordati,Italy,1970
Uses
Different sources of media describe the Uses of 356-12-7 differently. You can refer to the following data:
1. Glucocorticoid; anti-inflammatory.
2. Fluocinonide (Lidex, Lidex E, Fluonex) is a synthetic fluorinated corticosteroid.
Indications
Fluocinonide (Lidex, Lidex E, Fluonex) is a synthetic fluorinated corticosteroid.
Manufacturing Process
To a suspension of 500 mg of 6α-fluoro-triamcinolone in 75 ml of acetone is
added 0.05 milliliters of 72% perchloric acid and the mixture agitated-at room
temperature for 3 hours. During this period the crystals gradually dissolve and
the clear solution is neutralized with dilute bicarbonate and the acetone
removed in vacuo. The resulting crystalline suspension is filtered and the crystals washed with water. The dried material is recrystallized from 95%
alcohol to give the pure acetonide.A solution of 50 mg of 6α-fluoro-triamcinolone acetonide in 1 ml of pyridine
and 1 ml of acetic anhydride is allowed to stand at room temperature for 18
hours. Removal of the reagents in vacuo gives a crystalline residue which
after crystallization from acetone-hexane gives the pure 16α,17α-
isopropylidene 6α-fluoro-triamcinolone 21 acetate (fluocinonide), as described
in US Patent 3,197,469.
Brand name
Lidex (Medicis); Vanos (Medicis).
Therapeutic Function
Antiinflammatory, Glucocorticoid
Biochem/physiol Actions
Flucinonide is a fluorinated glucocorticid that is used as a topical anti-inflammatory agent. Recently, flucinonide and other fluorinated glucocorticolids were identified as smoothend agonists. Flucinonide induces expression of Gli-reporter luciferase in Shh-LIGHT2 cells.
Check Digit Verification of cas no
The CAS Registry Mumber 356-12-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,5 and 6 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 356-12:
(5*3)+(4*5)+(3*6)+(2*1)+(1*2)=57
57 % 10 = 7
So 356-12-7 is a valid CAS Registry Number.
InChI:InChI=1/C26H32F2O7/c1-13(29)33-12-20(32)26-21(34-22(2,3)35-26)10-15-16-9-18(27)17-8-14(30)6-7-23(17,4)25(16,28)19(31)11-24(15,26)5/h6-8,15-16,18-19,21,31H,9-12H2,1-5H3/t15-,16-,18-,19-,21+,23-,24-,25-,26+/m0/s1
356-12-7Relevant articles and documents
Preparation of high specific activity tritium labeled 6α,9,-difluoro- 11 β,21-dihydroxy- 16α,17-[(1-methylethylidene)bis(oxy)]pregna- 1,4-diene-3,20-one, fluocinolone acetonide
Zhong,Lewin, Anita H.
, p. 103 - 109 (2009)
Fluocinolone acetonide was tritiated by selective reduction of the 1,2-double bond of the O-protected analog under tritium, followed by re-establishment of the 1,2-double bond and deprotection. Protection of both hydroxyl functionalities was required. The product was obtained with specific activity 36.8Ci/mmol. Copyright
Synthetic method for preparing 16,17 ketal
-
Paragraph 0035-0039, (2020/04/06)
The invention relates to a synthetic method for preparing 16,17 ketal, particularly to applications of methanesulfonic acid and microwaves in the synthetic method, wherein the reaction speed and the content can be improved.
NOVEL PROCESS FOR PREPARATION OF CORTICOSTEROIDS
-
, (2018/03/25)
The present invention discloses a process for the preparation of pregnadiene derivatives having formula I, their stereoisomer and intermediate thereof. Formula I wherein each substituent is independently, R1 and R2 is hydrogen or C1 –C8straight, branched alkyl chain, saturated or unsaturated cycloalkyl; R3 is hydrogen or wherein R5 represents C1-C8 straight, branched alkyl chain or cycloalkyl; R4 is hydrogen or halogen; R6 is hydrogen or halogen;
