356055-77-1

Basic information

• Product Name: 4-(1H,1H,2H,2H-PERFLUORODECYL)BENZYL ALCOHOL
• Synonyms: 4-(1H,1H,2H,2H-PERFLUORODECYL)BENZYL ALCOHOL;4-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-HEPTADECAFLUORODECYL)BENZYL ALCOHOL;4-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-Heptadecafluorodecyl)benzyl alcohol >=97%
• CAS NO: 356055-77-1
• Molecular Formula: C₁₇H₁₁F₁₇O
• Molecular Weight: 554.24
• Mol File: 356055-77-1.mol
• Article Data: 3

Chemical Properties

• Melting Point: 81-85 °C
• Boiling Point: 323.564°C at 760 mmHg
• Flash Point: 149.486°C
• Appearance: /
• Density: 1.535g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.371
• PKA: 14.43±0.10(Predicted)
• CAS DataBase Reference: 4-(1H,1H,2H,2H-PERFLUORODECYL)BENZYL ALCOHOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(1H,1H,2H,2H-PERFLUORODECYL)BENZYL ALCOHOL(356055-77-1)
• EPA Substance Registry System: 4-(1H,1H,2H,2H-PERFLUORODECYL)BENZYL ALCOHOL(356055-77-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 356055-77-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C17H11F17O/c18-10(19,6-5-8-1-3-9(7-35)4-2-8)11(20,21)12(22,23)13(24,25)14(26,27)15(28,29)16(30,31)17(32,33)34/h1-4,35H,5-7H2

Upstream product

• 99768-12-4 4-methoxycarbonylphenylboronic acid 
• 589-87-7 1,4-bromoiodobenzene 
• 2043-53-0 2-(n-perfluorooctyl)ethyl iodide 
• 59016-93-2 p-hydroxymethylphenylboronic acid 
• 195324-88-0 1-(4'-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecane 
• 495388-44-8 4-((E)-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-Heptadecafluoro-dec-1-enyl)-benzoic acid methyl ester 
• 21652-58-4 1H,1H,2H-perfluorodecene 
• 619-42-1 4-methoxycarbonylphenyl bromide 

Downstream Products

• 495388-41-5 4-(1H,1H,2H,2H-perfluorodecyl)benzyl chloroformate 
• 556050-49-8 carbonic acid 2,5-dioxopyrrolidin-1-yl ester 4-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)benzyl ester 
• 1585235-84-2 15-(4-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)phenyl)-1,1,1-triphenyl-2,5,8,11,14-pentaoxapentadecane 
• 1585235-85-3 C₂₅H₂₇F₁₇O₅ 
• 1585235-86-4 27-(4-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)phenyl)-1,1,1-triphenyl-2,5,8,11,14,17,20,23,26-nonaoxaheptacosane 
• 1585235-87-5 ((3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)phenyl)-2,5,8,11,14,17,20,23-octaoxapentacosan-25-ol 
• 1585235-88-6 9-(4-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)phenyl)-1,1,1-triphenyl-2,5,8,11,14,17,20,23,26,29,32,35,38-tridecaoxanonatriacontane 
• 1313585-46-4 tert-butyl methyl(4-(2-perfluoroctylethyl)benzyloxy)carbamate 
• 1313585-74-8 C₃₈H₄₂F₁₇NO₅ 
• 1313585-78-2 C₃₆H₃₀F₁₇NO₃S₂ 
• 1313585-77-1 C₃₅H₃₀F₁₇NO₃S 
• 1313585-76-0 C₄₀H₃₃F₁₇N₂O₄S 
• 1313585-45-3 tert-butyl 4-(2-perfluoroctylethyl)benzyloxycarbamate 
• 1313585-72-6 C₃₈H₃₃F₁₇N₂O₅S 

Relevant articles and documents

Fluorous synthesis of mono-dispersed poly(ethylene glycols)

Mono-dispersed poly(ethylene glycols) (PEGs) are of great value in the development of biopharmaceuticals. However, tedious synthesis limits the availability of mono-dispersed PEGs. To address this issue, a fluorous synthesis of mono-dispersed PEGs, discretely PEGylated surfactants and 19F magnetic resonance imaging (MRI) agents has been developed. During the synthesis, both fluorous and normal phase silica gel-based solid-phase extractions were successfully employed to simplify the purifications. This synthesis provided an easy access to valuable mono-dispersed PEGs and related molecules for biomedical application on multi-gram scales.

Thiol additions to acrylates by fluorous mixture synthesis: Relative control of elution order in demixing by the fluorous tag and the thiol substituent

All possible combinations of a series of three fluorous benzyl tags and three acrylates have been made. The resulting acrylate esters were combined in groups of three (one of each tag) and the resulting mixtures were reacted with a mixture of four thiols under standard conditions to effect conjugate addition. Analysis of the resulting libraries by fluorous hplc showed a primary separation based on the tag and revealed reliable secondary separations based on the thiol and the acrylate. The primary and secondary separations were used together in a preparative 'mixture of mixtures' experiment in which one of the tagged acrylate mixtures was reacted with a mixture of three thiols. The resulting nine component mixture was demixed by fluorous and reverse phase hplc and then detagged to give all nine final products in pure form.