357426-12-1 Usage
Description
Methyl 3-(aminomethyl)-2,3-dihydro-1H-indene-1-carboxylate is a complex organic chemical compound characterized by the presence of a methyl group, an aminomethyl group, and a carboxylate group, all connected to a central indene ring. methyl 3-(aminomethyl)-2,3-dihydro-1H-indene-1-carboxylate is known for its potential as a versatile intermediate in the synthesis of various chemical products, particularly in the pharmaceutical and agrochemical industries, where it can be utilized to create biologically active compounds.
Uses
Used in Pharmaceutical Industry:
Methyl 3-(aminomethyl)-2,3-dihydro-1H-indene-1-carboxylate is used as a building block for the synthesis of biologically active compounds due to its unique structural features and reactivity, contributing to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, methyl 3-(aminomethyl)-2,3-dihydro-1H-indene-1-carboxylate is employed as an intermediate in the production of various agrochemicals, leveraging its chemical properties to enhance the effectiveness of these products in agricultural applications.
Used in Organic Synthesis:
Methyl 3-(aminomethyl)-2,3-dihydro-1H-indene-1-carboxylate is utilized as a versatile intermediate in organic synthesis, allowing for the creation of a wide range of chemical products through its ability to participate in various chemical reactions and form new compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 357426-12-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,5,7,4,2 and 6 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 357426-12:
(8*3)+(7*5)+(6*7)+(5*4)+(4*2)+(3*6)+(2*1)+(1*2)=151
151 % 10 = 1
So 357426-12-1 is a valid CAS Registry Number.
InChI:InChI=1/C12H15NO2/c1-15-12(14)11-6-8(7-13)9-4-2-3-5-10(9)11/h2-5,8,11H,6-7,13H2,1H3
357426-12-1Relevant articles and documents
Synthesis of (1-(aminomethyl)-2,3-dihydro-1H-inden-3-yl)methanol: Structural confirmation of the main band impurity found in Varenicline starting material
Busch, Frank R.,Concannon, Paul E.,Handfield, Robert E.,McKinley, Jason D.,McMahon, Megan E.,Singer, Robert A.,Watson, Timothy J.,Withbroe, Gregory J.,Stivanello, Mariano,Leoni, Lucia,Bezze, Chiara
, p. 441 - 447 (2008)
Described here is the synthesis of (1-(aminomethyl)-2,3-dihydro-1H-inden-3- yl)methanol 1, the previously unidentified impurity found in the synthesis of 2,1 providing a confirmation of the structure. Fabbrica Italiano Sintetici (FIS), working in conjunction with Pfizer Groton, reported an unidentified impurity, referred to as the "main band impurity", in 2 at levels of 0.4 to 0.8%. The structure was postulated to be 1, the open-ring product of the lithium aluminum hydride (LAH) reduction of 3 to 2. Although the cis isomer of 1 was previously reported in the literature,2 a much shorter racemic synthesis was developed using intermediates employed for the production of Varenicline. Several reducing agents were screened for the synthesis of 1, with LiAlH4 followed by basic workup conditions giving optimal results. High performance liquid chromatography (HPLC) analysis ultimately confirmed the structure of 1 as the main band impurity generated during the synthesis of 2. Copyright Taylor & Francis Group, LLC.
A general route to the synthesis of 1,5-methano- and 1,5-ethano-2, 3,4,5-tetrahydro-1h-3-benzazepines
O'Donnell, Christopher J.,Singer, Robert A.,Brubaker, Jason D.,McKinley, Jason D.
, p. 5756 - 5759 (2007/10/03)
A general approach to preparing 1,5-methano-(1) and l,5-ethano-2,3,4,5- tetrahydro-lff-3-benzazepine (2) is discussed. This strategy involves converting an indanone or tetralone (4) to a cyanohydrin (3) which is subjected to hydrogenolysis followed by lac