35779-35-2

Basic information

• Product Name: DIPYRIDIN-3-YLMETHANONE
• Synonyms: Nsc170628;dipyridin-3-ylmethanone(SALTDATA: FREE)
• CAS NO: 35779-35-2
• Molecular Formula: C₁₁H₈N₂O
• Molecular Weight: 184.2
• Mol File: 35779-35-2.mol
• Article Data: 10

Chemical Properties

• Melting Point: 115.5-117.0 °C
• Boiling Point: 346.8 °C at 760 mmHg
• Flash Point: 167.6 °C
• Appearance: /
• Density: 1.196 g/cm³
• Vapor Pressure: 5.63E-05mmHg at 25°C
• Refractive Index: 1.593
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 2.81±0.10(Predicted)
• CAS DataBase Reference: DIPYRIDIN-3-YLMETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: DIPYRIDIN-3-YLMETHANONE(35779-35-2)
• EPA Substance Registry System: DIPYRIDIN-3-YLMETHANONE(35779-35-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• Hazardous Substances Data: 35779-35-2(Hazardous Substances Data)

Usage

General Description

Dipyridin-3-ylmethanone, also known as 3-pyridylmethanone, is a chemical compound with the molecular formula C7H7NO. It is a yellow solid that is used as an intermediate in organic synthesis. It is commonly used in the production of pharmaceuticals, agrochemicals, and functional materials. Dipyridin-3-ylmethanone has a wide range of applications due to its ability to participate in various chemical reactions, including condensation and reduction reactions. It is also used as a building block in the synthesis of other organic compounds, making it a versatile and valuable chemical in the field of organic chemistry. Proper precautions should be taken when handling and storing dipyridin-3-ylmethanone, as it may pose hazards to human health and the environment.

InChI:InChI=1/C11H8N2O/c14-11(9-3-1-5-12-7-9)10-4-2-6-13-8-10/h1-8H

Upstream product

• 60573-68-4 3-pyridyllithium 
• 100-54-9 pyridine-3-carbonitrile 
• 614-18-6 3-pyridinecarboxylic acid ethyl ester 
• 626-55-1 3-Bromopyridine 
• 93-60-7 methyl 3-pyridinecarboxylate 
• 109-72-8 n-butyllithium 
• 220565-63-9 pyridin-3-ylzinc(II) bromide 
• 28122-96-5 S-phenyl pyridine-3-carbothioate 
• 500-22-1 3-pyridinecarboxaldehyde 
• 59-67-6 nicotinic acid 
• 89667-15-2 α-(3-Pyridyl)-3-pyridinmethanol 

Downstream Products

• 879081-88-6 2,6-di-tert-butyl-4-(hydroxy-di-pyridin-3-yl-methyl)-phenol 
• 1355718-60-3 (dipyridin-3-ylmethyl)triphenylphosphonium bromide 
• 1600563-75-4 (2,4-dichloro-3-phenylquinolin-6-yl)(dipyridin-3-yl)methanol trifluoroacetate 
• 89667-15-2 α-(3-Pyridyl)-3-pyridinmethanol 
• 78210-43-2 5,5-methylenebis(pyridine) 
• 879081-80-8 2,6-di-tert-butyl-4-(di-pyridin-3-yl-methylene)-cyclohexa-2,5-dienone 
• 22125-05-9 Phenyl-di-[3]pyridyl-methanol 

Relevant articles and documents

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Fukuyama Cross-Coupling Approach to Isoprekinamycin: Discovery of the Highly Active and Bench-Stable Palladium Precatalyst POxAP

An efficient and user-friendly palladium(II) precatalyst, POxAP (post-oxidative-addition precatalyst), was identified for use in Fukuyama cross-coupling reactions. Suitable for storage under air, the POxAP precatalyst allowed reaction between thioesters and organozinc reagents with turnover numbers of ～90000. A series of 23 ketones were obtained with yields ranging from 53 to 99%. As proof of efficacy, an alternative approach was developed for the synthesis of a key precursor of the natural product isoprekinamycin.

Palladium-catalyzed synthesis of diaryl ketones from aldehydes and (hetero)aryl halides via C-H bond activation

We developed a palladium-catalyzed C-H transformation that enabled the synthesis of ketones from aldehydes and (hetero)aryl halides. The use of picolinamide ligands was key to achieving the transformation. Heteroaryl ketones, as well as diaryl ketones, were synthesized in good to excellent yields, even in gram-scale, using this reaction. Results of density functional theory (DFT) calculations support the C-H bond activation pathway.

NEW COMPOUNDS I/418

There is provided compounds of formula I, wherein R1 to R7 have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.