35784-26-0

Basic information

• Product Name: 7-(benzyloxy)-3-hydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one
• Synonyms: 7-(benzyloxy)-3-hydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one
• CAS NO: 35784-26-0
• Molecular Weight: 374.393
• Mol File: 35784-26-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 7-(benzyloxy)-3-hydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-(benzyloxy)-3-hydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one(35784-26-0)
• EPA Substance Registry System: 7-(benzyloxy)-3-hydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one(35784-26-0)

Safety Data

• Hazardous Substances Data: 35784-26-0(Hazardous Substances Data)

Upstream product

• 81674-92-2 (E)-1-(4-(benzyloxy)-2-hydroxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one 
• 29682-12-0 1-[4-(benzyloxy)-2-hydroxyphenyl]ethanone 
• 123-11-5 4-methoxy-benzaldehyde 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 

Downstream Products

• 1096657-28-1 C₃₄H₃₂O₁₂ 
• 1096657-21-4 C₃₇H₃₆O₁₄ 
• 1096657-24-7 C₃₇H₃₆O₁₄ 
• 35784-27-1 3-acetoxy-7-benzyloxy-2-(4-methoxy-phenyl)-chromen-4-one 
• 552-26-1 3,7-dihydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one 

Relevant articles and documents

Design of Development Candidate eFT226, a First in Class Inhibitor of Eukaryotic Initiation Factor 4A RNA Helicase

Dysregulation of protein translation is a key driver for the pathogenesis of many cancers. Eukaryotic initiation factor 4A (eIF4A), an ATP-dependent DEAD-box RNA helicase, is a critical component of the eIF4F complex, which regulates cap-dependent protein synthesis. The flavagline class of natural products (i.e., rocaglamide A) has been shown to inhibit protein synthesis by stabilizing a translation-incompetent complex for select messenger RNAs (mRNAs) with eIF4A. Despite showing promising anticancer phenotypes, the development of flavagline derivatives as therapeutic agents has been hampered because of poor drug-like properties as well as synthetic complexity. A focused effort was undertaken utilizing a ligand-based design strategy to identify a chemotype with optimized physicochemical properties. Also, detailed mechanistic studies were undertaken to further elucidate mRNA sequence selectivity, key regulated target genes, and the associated antitumor phenotype. This work led to the design of eFT226 (Zotatifin), a compound with excellent physicochemical properties and significant antitumor activity that supports clinical development.

Synthesis of a library of glycosylated flavonols

Flavonols are an important class of natural products isolated from plants. Some glycosylated flavonols showed very interesting biological activities. A library of flavonols has been made through Algar-Flynn-Oyamada reaction from 2′-hydroxyacetophenones an