3585-52-2 Usage
Description
(2RS)-2-(4-ETHYLPHENYL)PROPANOIC ACID, also known as p-Ethylhydratropic Acid, is a phenylacetic acid derivative with potential anti-inflammatory properties. It is an impurity found in Ibuprofen (I140000), a widely used nonsteroidal anti-inflammatory drug (NSAID).
Uses
Used in Pharmaceutical Industry:
(2RS)-2-(4-ETHYLPHENYL)PROPANOIC ACID is used as an impurity in Ibuprofen (I140000) for its potential anti-inflammatory activities. It is important to monitor and control the levels of this impurity in Ibuprofen to ensure the safety and efficacy of the drug.
Used in Research and Development:
(2RS)-2-(4-ETHYLPHENYL)PROPANOIC ACID can be used as a research compound to study its anti-inflammatory properties and potential applications in the development of new pharmaceuticals or as a reference standard in analytical methods for the detection and quantification of impurities in Ibuprofen.
Synthesis Reference(s)
Tetrahedron Letters, 31, p. 7495, 1990 DOI: 10.1016/S0040-4039(00)88526-3
Check Digit Verification of cas no
The CAS Registry Mumber 3585-52-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,5,8 and 5 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 3585-52:
(6*3)+(5*5)+(4*8)+(3*5)+(2*5)+(1*2)=102
102 % 10 = 2
So 3585-52-2 is a valid CAS Registry Number.
3585-52-2Relevant articles and documents
Preparation method of ibuprofen impurity N
-
Paragraph 0007; 0026, (2021/03/30)
The invention provides a preparation method of an ibuprofen impurity N, and belongs to the technical field of preparation of drug impurity standard substances, and the preparation method comprises thefollowing steps: step 1, carrying out coupling reaction
A one-pot synthesis of ibuprofene involving three consecutive steps of superbase metalation
Faigl,Schlosser
, p. 3369 - 3370 (2007/10/02)
A one-pot reaction sequence consisting of three consecutive metalation and electrophilic substitution stages leads to 2-(4-isobutylphenyl)propanoic acid with 52% over-all yield. A crucial step is the alkylation of deprotonated p-ethyltoluene with isopropyl bromide. In general terms, sec-alkyl halides and benzyl or allyl type alkalimetal reagents undergo coupling reactions with surprising ease.
Process for the preparation of α-arylalkanoic acids
-
, (2008/06/13)
α-Arylalkanoic acids are prepared by a method comprising the step of reacting an alkylaromatic compound corresponding to the desired α-arylalkanoic acid with a new metallation reagent solution. The reagent comprises the reaction product of alkyllithium or aryllithium and about two to five molar equivalents of potassium tert-alkoxide in a trialkylamine solvent.
