35879-53-9

Basic information

• Product Name: ETHYL 4-(AMINOMETHYL)CYCLOHEXANECARBOXYLATE
• Synonyms: ETHYL 4-(AMINOMETHYL)CYCLOHEXANECARBOXYLATE;(1r,4r)-ethyl 4-(aminomethyl)cyclohexanecarboxylate;trans-4-(Aminomethyl)cyclohexanecarboxylic acid ethyl ester;trans-Ethyl 4-(Aminomethyl)cyclohexanecarboxylate
• CAS NO: 35879-53-9
• Molecular Formula: C₁₀H₁₉NO₂
• Molecular Weight: 185.27
• Mol File: 35879-53-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 259.264°C at 760 mmHg
• Flash Point: 121.921°C
• Appearance: /
• Density: 1g/cm³
• Vapor Pressure: 0.013mmHg at 25°C
• Refractive Index: 1.468
• CAS DataBase Reference: ETHYL 4-(AMINOMETHYL)CYCLOHEXANECARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 4-(AMINOMETHYL)CYCLOHEXANECARBOXYLATE(35879-53-9)
• EPA Substance Registry System: ETHYL 4-(AMINOMETHYL)CYCLOHEXANECARBOXYLATE(35879-53-9)

Safety Data

• Hazardous Substances Data: 35879-53-9(Hazardous Substances Data)

Usage

General Description

ETHYL 4-(AMINOMETHYL)CYCLOHEXANECARBOXYLATE is a chemical compound with the molecular formula C11H19NO2. It is an ester derivative of cyclohexanecarboxylic acid, with an ethyl group attached to the carboxyl group and an aminomethyl group attached to the cyclohexane ring. ETHYL 4-(AMINOMETHYL)CYCLOHEXANECARBOXYLATE is commonly used in the pharmaceutical industry as a building block for the synthesis of various medications. It has potential applications in the development of drugs for the treatment of neurological disorders, as well as for its potential use as a local anesthetic. Additionally, it may also have uses in the agrochemical industry for the development of new pesticides.

InChI:InChI=1/C10H19NO2/c1-2-13-10(12)9-5-3-8(7-11)4-6-9/h8-9H,2-7,11H2,1H3

Upstream product

• 140-88-5 ethyl acrylate 
• 98837-34-4 ethyl 3-hydroxy-2-methylenebutanoate 
• 107-13-1 acrylonitrile 
• 1197-18-8 trans-4-aminomethyl-cyclohexyl-carboxylic acid 
• 64-17-5 ethanol 

Downstream Products

• 438190-93-3 1'-(trans-4-Ethoxycarbonyl-cyclohexylmethyl)carbamoyl-spiro [isobenzofuran-1,4'piperidin]3-one 
• 180046-90-6 trans 4-(tert-butyloxycarbonylaminoethyl)cyclohexaneacetaldehyde 

Relevant articles and documents

Production of Copolyester Monomers from Plant-Based Acrylate and Acetaldehyde

PCTA is an important copolyester that has been widely used in our daily necessities. Currently, its monomers are industrially produced from petroleum-derived xylene. To reduce the reliance on fossil energy, we herein disclose an alternative route to acces

A structure-activity analysis of biased agonism at the dopamine D2 receptor

Biased agonism offers an opportunity for the medicinal chemist to discover pathway-selective ligands for GPCRs. A number of studies have suggested that biased agonism at the dopamine D2 receptor (D2R) may be advantageous for the treatment of neuropsychiatric disorders, including schizophrenia. As such, it is of great importance to gain insight into the SAR of biased agonism at this receptor. We have generated SAR based on a novel D2R partial agonist, tert-butyl (trans-4-(2-(3,4-dihydroisoquinolin- 2(1H)-yl)ethyl)cyclohexyl)carbamate (4). This ligand shares structural similarity to cariprazine (2), a drug awaiting FDA approval for the treatment of schizophrenia, yet displays a distinct bias toward two different signaling end points. We synthesized a number of derivatives of 4 with subtle structural modifications, including incorporation of cariprazine fragments. By combining pharmacological profiling with analytical methodology to identify and to quantify bias, we have demonstrated that efficacy and biased agonism can be finely tuned by minor structural modifications to the head group containing the tertiary amine, a tail group that extends away from this moiety, and the orientation and length of a spacer region between these two moieties.

Medicinal chemical studies on antiplasmin drugs. 4. Chemical modification of trans-4-aminomethylcyclohexanecarboxylic acid and its effect on antiplasmin activity.

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