35883-86-4Relevant articles and documents
Synthesis of 2-nitro- and 2,2′-dinitrobiphenyls by means of the suzuki cross-coupling reaction
Gonzalez, Raquel Rodriguez,Liguori, Lucia,Carrillo, Alberto Martinez,Bjorsvik, Hans-Rene
, p. 9591 - 9594 (2007/10/03)
Mechanistic investigations and protocols for the synthesis of 2-nitrobiphenyls and 2,2′-dinitrobiphenyls are disclosed. It is revealed that obstacles appear during the transmetalation step when the phenylboronic acid is substituted with a nitro group in the 2-position, whereas when substituted in the 3- or 4-positions, the reaction follows similar patterns as found in the electrophilic substitution of nitrobenzenes, an observation that may be attributed to the elimination step of the catalytic cycle.