35898-31-8

Basic information

• Product Name: Thymidine, 5'-acetate
• Synonyms: Thymidine,5'-acetate
• CAS NO: 35898-31-8
• Molecular Formula: C12H16N2O6
• Molecular Weight: 284.269
• Mol File: 35898-31-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Thymidine, 5'-acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Thymidine, 5'-acetate(35898-31-8)
• EPA Substance Registry System: Thymidine, 5'-acetate(35898-31-8)

Safety Data

• Hazardous Substances Data: 35898-31-8(Hazardous Substances Data)

Upstream product

• 108-24-7 acetic anhydride 
• 50-89-5 thymidine 
• 6979-97-1 3',5'-diacetylthymidine 

Downstream Products

• 19192-40-6 TpdA 
• 129835-23-0 5'-O-acetyl-3'-O-<carbamoyl>thymidine 
• 76054-81-4 3'-O-(4,4'-dimethoxytrityl)thymidine 
• 3416-05-5 3'-Deoxythymidine 
• 76054-82-5 5'-O-acetyl-3'-O-dimethoxytrityl-2'-deoxythymidine 

Relevant articles and documents

Semisynthetic peptide-lipase conjugates for improved biotransformations

An efficient chemoselective method for the creation of semisynthetic lipases by site-specific incorporation of tailor-made peptides on the lipase-lid site was developed. These new enzymes showed excellent improved specificity and regio- or enantioselectivity in different biotransformations.

Conformational Transmission in Nucleotides Containing Trigonal Bipyramidal Phosphorus as the Internucleoside Linkage

A set of nucleotide analogues containing a stable trigonal bipyramidal phosphorus (PV TBP) moiety (5-11) has been developed, and their conformational properties were studied with 300- and 500-MHz 1H NMR.In the solvent acetone-d6, it is found that the conformation of the model compounds is determined by a hydrogen bond between the backbone atom O5', and the base proton H6 (pyrimidine base) or H8 (purine base), resulting in a preference for the standard gauche(+) conformation around the C4'-C5' bond.In the hydrogen bond disrupting solvent DMSO-d6, the PV TBP nucleotides 5-8 clearly show conformational transmission, i.e., a preference for the unusual gauche(-) (g-) rotamer around the C4'-C5' bond is found.This structural distortion opposes stacking of the bases, as is confirmed by the observation that the preference for g- is strongest for 7 and 8, in which stacking is eliminated.The present results provide support to our earlier proposition that formation of PV TBP locations in DNA can lead to a marked change of the secondary structure (Buck, H.M.Recl.Trav.Chim.Pays-Bas 1980, 99, 181).