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359-13-7

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359-13-7 Usage

Chemical Properties

Colorless Liquid

Uses

2,2-Difluoroethanol is used as a chemical intermediates. It has wide applications in medicine and fluoropolymers.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 23, p. 985, 1980 DOI: 10.1021/jm00183a005

Check Digit Verification of cas no

The CAS Registry Mumber 359-13-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,5 and 9 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 359-13:
(5*3)+(4*5)+(3*9)+(2*1)+(1*3)=67
67 % 10 = 7
So 359-13-7 is a valid CAS Registry Number.
InChI:InChI=1/C2H2ClFO/c3-1-2(4)5/h1H2

359-13-7 Well-known Company Product Price

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  • (Code)Product description
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  • TCI America

  • (D4128)  2,2-Difluoroethanol  >98.0%(GC)

  • 359-13-7

  • 5g

  • 690.00CNY

  • Detail
  • Alfa Aesar

  • (B22201)  2,2-Difluoroethanol, 97%   

  • 359-13-7

  • 1g

  • 352.0CNY

  • Detail
  • Alfa Aesar

  • (B22201)  2,2-Difluoroethanol, 97%   

  • 359-13-7

  • 5g

  • 1403.0CNY

  • Detail

359-13-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,2-Difluoroethanol

1.2 Other means of identification

Product number -
Other names CHF2CH2OH

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:359-13-7 SDS

359-13-7Relevant articles and documents

In situ generation of difluoromethyl diazomethane for [3+2] cycloadditions with alkynes

Mykhailiuk, Pavel K.

, p. 6558 - 6561 (2015)

A novel approach to agrochemically important difluoromethyl-substituted pyrazoles has been developed based on the elusive reagent CF2HCHN2, which was synthesized (generated in situ) for the first time and employed in [3+2] cycloaddition reactions with alkynes. The reaction is extremely practical as it is a one-pot process, does not require a catalyst or the isolation of the potentially toxic and explosive gaseous intermediate, and proceeds in a common solvent, namely chloroform, in air. The reaction is also scalable and allows for the preparation of the target pyrazoles on gram scale. A new reagent: The elusive chemical reagent CF2HCHN2 was generated in situ for the first time and further reacted with alkynes in a [3+2] cycloaddition reaction. This transformation constitutes a novel and efficient approach to agrochemically important difluoromethylated pyrazoles.

Gas phase hydrogenolysis of methyl difluoroacetate to 1,1-difluoroethanol over Ru/C catalysts

Zheng, Su-Zhen,Cao, Xiao-Yan,Zhou, Qiang,Wang, Shu-Hua,Hu, Geng-Shen,Lu, Ji-Qing,Luo, Meng-Fei,Wang, Yue-Juan

, p. 132 - 135 (2013)

Ru/C catalysts were prepared by an impregnation method and their catalytic properties were tested for hydrogenolysis methyl difluoroacetate to difluoroethanol. The catalysts were characterized by X-ray powder diffraction (XRD), transmission electron microscopy (TEM), CO chemisorption and H 2 temperature-programmed reduction (H2-TPR). The effects of reaction temperature, Ru content and reduction temperature of the Ru/C catalysts on the reaction were investigated. It was found that with increasing Ru contents in the Ru/C catalysts, the methyl difluoroacetate conversion, the selectivity to difluoroethanol and the TOF value first increased and then decreased. A 3Ru/C catalyst reduced at 400 °C exhibited the highest selectivity to difluoroethanol (93.5%) and the highest activity (39.5%). It was also found that the Ru/C catalyst showed a good stability of catalytic hydrogenolysis of methyl difluoroacetate within 100 h.

Method for preparing 2,2-difluoroethanol

-

Paragraph 0069-0074, (2021/04/14)

The invention discloses a method for preparing 2,2-difluoroethanol. The method for preparing 2,2-difluoroethanol comprises the following steps: step (i): performing transesterification on 2,2-difluoroethyl acetate in the presence of ethanol and optionally a base.

SYNTHESIS OF FLUORO HEMIACETALS VIA TRANSITION METAL-CATALYZED FLUORO ESTER AND CARBOXAMIDE HYDROGENATION

-

Paragraph 0237-0238; 0259-0260, (2020/11/24)

This application is directed to use of transition metal-ligand complexes to hydrogenate fluorinated esters and carboxamides into fluorinated hemiacetals. Methods for synthesis of certain ligands are also provided.

Diaminodiphosphine tetradentate ligand and ruthenium complex thereof, and preparation methods and applications of ligand and complex

-

Paragraph 0312-0315, (2019/11/04)

The invention discloses a diaminodiphosphine tetradentate ligand and a ruthenium complex thereof, and preparation methods and applications of the ligand and the complex, and provides a ruthenium complex represented by a formula I, wherein L is a diaminodiphosphine tetradentate ligand represented by a formula II, and X and Y are respectively and independently chlorine ion, bromine ion, iodine ion,hydrogen negative ion or BH4. According to the present invention, the ruthenium complex exhibits excellent catalytic activity in the catalytic hydrogenation reactions of ester compounds, has high yield and high chemical selectivity, is compatible with conjugated and non-conjugated carbon-carbon double bond, carbon-carbon triple bond, epoxy, halogen, carbonyl and other functional groups, and hasgreat application prospects.

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