35963-20-3 Usage
L-Camphorsulfonic acid
Camphor sulfonic acid includes L-camphor sulfonic acid, D-camphor sulfonic acid and racemic camphor sulfonic acid these three isomers.
It is a kind of white columnar crystals with the melting point of 193°C (decomposition). [α]D20+24° (water). It is Slightly soluble in ethanol, insoluble in ether, soluble in sodium hydroxide and sodium carbonate solution. L-camphor sulfonic acid could be produced from reaction between camphor, sulfuric acid and acetic anhydride.It has a lot of functions such as exciting the respiratory center, the vascular movement center and myocardium. Its sodium salt plays pharmaceutical role in medicine.
Camphor sulfonic acid sodium salt is a kind of white crystalline powder. It is odorless and tastes bitter and then sweet. It is easily absorb moisture and easily dissolve in the water and hot ethanol. So it should be shading confined preservation. it can Directly excite the medulla oblongata respiratory center and vascular movement center, and quicken and deepen the breath, rise the blood pressure; it also can directly excite the myocardium and strength the contraction of cardiac muscle as well as could increase the output.
It is applied the treatment of infectious disease, as well as the disease like central inhibition of poisoning caused by respiratory depression, fatigue, high fever, poisoning, heat stroke and other acute heart failure.
Uses
Different sources of media describe the Uses of 35963-20-3 differently. You can refer to the following data:
1. (1) It is also used for the racemization of optical isomers.
(2) It can be applied to the resolution of intermediate or isomer in medicine.
(3) It also could play a role as organic synthesis intermediates and resolving agent.
2. 1R)-(-)-10-Camphorsulfonic acid is a chiral derivative of Camphor.It has the following uses:
(1)It is also used for the racemization of optical isomers.
(2) It can be applied to the resolution of intermediate or isomer in medicine.
(3) It also could play a role as organic synthesis intermediates and resolving agent.
3. (1R)-(-)-Camphor-10-sulfonic acid, is used as a pharamaceutical intermediate and also used as a chiral derivative of Camp. It can also be used as resolving agents for chiral amines and other cations.
Production method
Camphor sulfonic acid is obtained from camphor and sulfuric acid by irradiation.
This method involves:
1) Adding the camphor and acetic anhydride to the pot.
2) Mixing it and making it dissolved.
3) Dripping sulfuric acid after cooling. And the reaction should be maintained at 44-45 °C for 48 hours. Then cool it to 6-7 °C.
4) Crystallizing, filtrating, washing with a small amount of acetic acid crystals, and dry it to get camphor sulfonic acid.
Physical properties
(1R)-(-)-10-Camphorsulfonic acid is a kind of prismatic crystals and its melting point is 193-195 ° C (decompose). It is Insoluble in ether and slightly soluble in glacial acetic acid and ethyl acetate. And it is and moisture in wet air.
Definition
ChEBI: The R enantiomer of camphorsulfonic acid.
General Description
(1R)-(-)-10-Camphorsulfonic acid is an HPLC derivatization reagent for UV/Vis detection. It is mainly employed for the resolution of bases.
Purification Methods
It forms prisms from AcOH or EtOAc, and is deliquescent in moist air. Store it in tightly stoppered bottles. The NH4 salt forms needles from H2O [] D ±20.5o (c 5, H2O). [Burgess & Lowry J Chem Soc 127 279 1925, Marsi et al. J Am Chem Soc [ 78 3063 1956.] The RS-acid recrystallises from AcOH. [60g of (±)-acid in 60mL of AcOH at 105o gave 40g of crystals has m 202-203o [Bartlett & Knox Org Synth 45 12 1965.] [Beilstein 11 IV 642.]
Check Digit Verification of cas no
The CAS Registry Mumber 35963-20-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,5,9,6 and 3 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 35963-20:
(7*3)+(6*5)+(5*9)+(4*6)+(3*3)+(2*2)+(1*0)=133
133 % 10 = 3
So 35963-20-3 is a valid CAS Registry Number.
InChI:InChI=1/C10H16O4S.H2O/c1-9(2)7-3-4-10(9,8(11)5-7)6-15(12,13)14;/h7H,3-6H2,1-2H3,(H,12,13,14);1H2
35963-20-3Relevant articles and documents
Voriconazole resolving agent (R)-10 - camphor sulfonic acid recovery method
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Paragraph 0028-0029; 0034-0035; 0037-0046, (2018/07/30)
The invention discloses a Voriconazole resolving agent (R)- 10 - camphorsulfonic acid recovery method, comprises the following steps: (1) alkali treatment: the Voriconazole is soluble in methylene chloride and water camphor sulfonate in the mixed solution of, adding alkali treatment of weak base aqueous solution, to be delaminated separation, keeps the water level for use; (2) the acidification process: in step (1) by adding a strong acid in the aqueous layer of the acidification process, then the concentration and evaporation drying to get the solid; the resulting solid under the heating condition is dissolved in the organic solvent, filtering, remain filtrate for use; (3) crystallization processing: the cyclohexane are added to step (2) in the filtrate obtained by, cooling crystallization, crystallization carried out upon completion of filtering, to obtain the (R)- 10 - camphorsulfonic acid. Voriconazole resolving agent (R)- 10 - camphorsulfonic acid recovery method has a simple separation, separation product has high optical purity, economic, environmental protection and the like.
Identification of small molecule sulfonic acids as ecto-5'-nucleotidase inhibitors
Raza, Rabia,Saeed, Aamer,Lecka, Joanna,Sévigny, Jean,Iqbal, Jamshed
, p. 1133 - 1139 (2013/01/15)
Ecto-5'-Nucleotidase inhibitors have great potential as anti-tumor agents. We have investigated biochemical properties of human and rat ecto-5'-Nucleotidases and characterized 19 small molecule sulfonic acid derivatives as potential inhibitors of ecto-5'-Nucleotidases. We identified 11 potent inhibitors of human and rat ecto-5'-Nucleotidases and checked their selectivity. Compound 10 (Sodium 2,4-dinitrobenzenesulfonate) with Ki value of 0.66 μM and 19 (N-(4- sulfamoylphenylcarbamothioyl) pivalamide) with Ki value of 0.78 μM were identified as the most potent inhibitors for human and rat ecto-5'-Nucleotidase, respectively. The present compounds have low molecular weights, water solubility and equal potency as compared to the reported inhibitors.
Polymorphic clopidogrel hydrogenesulphate form
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, (2008/06/13)
Novel orthorombic polymorph of clopidogrel hydrogen sulfate or hydrogen sulfate of methyl (+)-(S)-α-(2-chlorophenyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-5-acetate and a process for its preparation.
