3600-86-0

Basic information

• Product Name: 2,5-Dimethoxyphenethylamine
• Synonyms: 2-(2,5-Dimethoxyphenyl)ethanamine;RARECHEM AL BW 0357;2-(2,5-DIMETHOXY-PHENYL)-ETHYLAMINE;2,5-DIMETHOXYPHENETHYLAMINE;2,5-Dimethoxyphenylethylamine;2C-H;2,5-DIMETHOXYPHENETHYLAMIN 98.0%;2,5-Dimethoxyphenethylamine,97%
• CAS NO: 3600-86-0
• Molecular Formula: C₁₀H₁₅NO₂
• Molecular Weight: 181.23
• Product Categories: C9 to C10;Amines;Nitrogen Compounds;Aromatics;Miscellaneous Reagents
• Mol File: 3600-86-0.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 160 °C10 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: light yellow to colourless liquid
• Density: 1.089 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.5424(lit.)
• Storage Temp.: Refrigerator, Under Inert Atmosphere
• PKA: 9.72±0.10(Predicted)
• CAS DataBase Reference: 2,5-Dimethoxyphenethylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Dimethoxyphenethylamine(3600-86-0)
• EPA Substance Registry System: 2,5-Dimethoxyphenethylamine(3600-86-0)

Safety Data

• Hazard Codes: Xi,C
• Statements: 36/37/38-34
• Safety Statements: 26-37/39-45-36/37/39
• RIDADR: 1760
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 3600-86-0(Hazardous Substances Data)

Usage

Chemical Properties

Colorless to light yellow liqui

InChI:InChI=1/C10H15NO2/c1-12-9-3-4-10(13-2)8(7-9)5-6-11/h3-4,7H,5-6,11H2,1-2H3

Upstream product

• 14438-63-2 1-(2,5-dimethoxyphenyl)-2-nitroethanol 
• 72018-06-5 ethyl E-3-(2,5-dimethoxyphenyl)propanoate 
• 38489-74-6 trans-2,5-dimethoxycinnamic acid 
• 10538-49-5 3-(2,5-dimethoxyphenyl)propanoic acid 
• 93-02-7 2,5-dimethoxybenzaldehyde 
• 108536-18-1 β-dimethoxy-2,5 phenyl nitro ethylene 
• 436155-33-8 3-(2,5-dimethoxyphenyl)propanoylhydrazine 
• 72205-78-8 3-(2,5-dimethoxy-phenyl)-propionic acid amide 
• 40276-11-7 (E)-1,4-dimethoxy-2-(2-nitrovinyl) benzene 

Downstream Products

• 69226-57-9 (2,5-dimethoxy-phenethyl)-urea 
• 21581-41-9 2,5-dihydroxyphenylethylamine 
• 3489-95-0 (2,5-dimethoxy-phenethyl)-methyl-amine 
• 106274-40-2 N-<2-(2,5-dimethoxyphenyl)ethyl>acetamide 
• 106462-40-2 2-(3,4-Dimethoxy-phenyl)-N-[2-(2,5-dimethoxy-phenyl)-ethyl]-acetamide 
• 97796-51-5 1-[2-(2,5-Dimethoxy-phenyl)-ethyl]-2-hydroxy-2,4-diphenyl-1,2-dihydro-pyrrol-3-one 
• 194996-05-9 N-((tert-butoxy)carbonyl)-N'-(2-(phenyl)ethyl)-N''-(2-(2,5-dimethoxyphenyl)ethyl)iminodiacetic acid diamide 
• 194996-10-6 {[2-(2,5-Dimethoxy-phenyl)-ethylcarbamoyl]-methyl}-[(4-methoxy-benzylcarbamoyl)-methyl]-carbamic acid tert-butyl ester 
• 194996-11-7 {[2-(2,5-Dimethoxy-phenyl)-ethylcarbamoyl]-methyl}-{[2-(4-fluoro-phenyl)-ethylcarbamoyl]-methyl}-carbamic acid tert-butyl ester 
• 194996-08-2 {[2-(2,5-Dimethoxy-phenyl)-ethylcarbamoyl]-methyl}-{[2-(4-hydroxy-phenyl)-ethylcarbamoyl]-methyl}-carbamic acid tert-butyl ester 
• 194996-07-1 {[2-(2,5-Dimethoxy-phenyl)-ethylcarbamoyl]-methyl}-{[2-(4-methoxy-phenyl)-ethylcarbamoyl]-methyl}-carbamic acid tert-butyl ester 
• 194996-09-3 {[2-(2,5-Dimethoxy-phenyl)-ethylcarbamoyl]-methyl}-{[2-(3-methoxy-phenyl)-ethylcarbamoyl]-methyl}-carbamic acid tert-butyl ester 
• 66142-81-2 2-(4-bromo-2,5-dimethoxyphenyl)-1-aminoethane 
• 261789-00-8 2,5-Dimethoxy-4-nitrophenethylamine 

Relevant articles and documents

Synthesis of 25X-BOMes and 25X-NBOHs (X = H, I, Br) for pharmacological studies and as reference standards for forensic purposes

An expeditious method is reported for the synthesis of three NBOHs (25H-, 25I- and 25B-NBOH; 9–38% overall yield) and three NBOMes (25H-, 25I- and 25B-NBOMe; 7–33% overall yield) from salicylaldehyde and 2-methoxyaldehyde, respectively. The X-ray structures of 25H-, 25I- and 25B-NBOH.HCl were also determined. Our approach should provide a general entry for preparing such a class of substances for pharmacological and forensic purposes.

Two immunoassays for the detection of 2C-B and related hallucinogenic phenethylamines

Introduction: The use of new psychoactive substances as drugs of abuse has dramatically increased over the last years. Hallucinogenic phenethylamines gained particular popularity as they have both stimulating and psychedelic effects. Although generally perceived as safe, these illicit drugs pose a serious health risk; they have been linked to cases of severe poisoning or even deaths. Therefore, simple, cost-effective and reliable methods are needed for rapid determination of abused hallucinogens. Methods: For this purpose, two haptens derived from 2C-H were designed, synthesized and subsequently attached to a carrier protein. Polyclonal antibodies obtained from a rabbit immunized with one of the prepared immunogens were used for the development of two immunoassays. Results: In this study, a lateral flow immunoassay (LFIA) and an enzyme linked immunosorbent assay (ELISA) for the detection of 2C-B and related hallucinogenic phenethylamines in urine were developed. The presented LFIA is primarily suitable for on-site monitoring as it is simple and can provide a visual evidence of 2C-B presence within a few minutes. Its reasonable sensitivity (LODLFIA = 15 ± 7 ng mL?1) allows detection of the drug presence in urine after acute exposure. For greater accuracy, highly sensitive ELISA (LODELISA = 6 ± 3 pg mL?1) is proposed for toxicological quantitative analyses of positive samples captured by the LFIA. Discussion: The comparison of the ELISA with the well-established UHPLC-MS-MS method shows excellent agreement of results, which confirms good potential of the ELISA to be used for routine analyses of 2C-B and related hallucinogenic phenethylamines of both main sub-families.

Immunoassay for Phenethylamines of the 2C and DO Sub-Families

Immunoassay methods and their requisite components for the detection and determination of phenethylamines of the 2C and DO sub-families are described.