36043-49-9

Basic information

• Product Name: 2-aminophenanthrene-9,10-dione
• CAS NO: 36043-49-9
• Molecular Formula: C₁₄H₉NO₂
• Molecular Weight: 223.2268
• Mol File: 36043-49-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 482.7°C at 760 mmHg
• Flash Point: 245.7°C
• Density: 1.383g/cm³
• Vapor Pressure: 1.79E-09mmHg at 25°C
• Refractive Index: 1.707
• CAS DataBase Reference: 2-aminophenanthrene-9,10-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-aminophenanthrene-9,10-dione(36043-49-9)
• EPA Substance Registry System: 2-aminophenanthrene-9,10-dione(36043-49-9)

Safety Data

• Hazardous Substances Data: 36043-49-9(Hazardous Substances Data)

Usage

General Description

2-Aminophenanthrene-9,10-dione, also known as aminophenanthroquinone, is a chemical compound with the molecular formula C14H9NO2. It is a derivative of phenanthrenequinone, and its structure consists of a phenanthrene ring with a carbonyl group and an amino group attached to it. 2-aminophenanthrene-9,10-dione is a yellow to brown solid and is used in the synthesis of various organic compounds and dyes. It also has potential applications in the field of materials science and biochemistry. Additionally, it is important to note that 2-aminophenanthrene-9,10-dione is a potentially hazardous chemical and should be handled and stored with caution.

Upstream product

• 7647-01-0 hydrogenchloride 
• 604-95-5 2-nitrophenanthrene-9,10-dione 
• 861337-24-8 2-azido-phenanthrene-9,10-dione 
• 84-11-7 9,10-phenanthrenequinone 
• 7664-93-9 sulfuric acid 
• 7705-08-0 iron(III) chloride 

Downstream Products

• 121677-52-9 2-((Ξ)-2-amino-10-oxo-10H-[9]phenanthrylidene)-benzo[de]thiochromen-3-one 
• 861349-60-2 2-(2,4,6-trinitro-anilino)-phenanthrene-9,10-dione 
• 112273-09-3 dibenzo[a,c]phenazin-2-ylamine 
• 4088-81-7 2-hydroxy-phenanthrene-9,10-dione 

Relevant articles and documents

Potent reversible inhibitors of the protein tyrosine phosphatase CD45

The cytosolic portion of CD45, a major transmembrane glycoprotein found on nucleated hematopoietic cells, contains protein tyrosine phosphatase activity and is critical for T-cell receptor-mediated T-cell activation. CD45 inhibitors could have utility in the treatment of autoimmune disorders and organ graft rejection. A number of 9,10-phenanthrenediones were identified that reversibly inhibited CD45-mediated p-nitrophenyl phosphate (pNPP) hydrolysis. Chemistry efforts around the 9,10-phenanthrenedione core led to the most potent inhibitors known to date. In a functional assay, the compounds were also potent inhibitors of T-cell receptor-ediated proliferation, with activities in the low micromolar range paralleling their enzyme inhibition. It was also discovered that the nature of modification to the phenanthrenedione pharmacophore could affect selectivity for CD45 over PTP1B (protein tyrosine phosphatase 1B) or vice versa.

PTEN INHIBITORS

The therapeutic use of inhibitors of PTEN activity in the treatment of PTEN-mediated diseases, conditions, and injuries is disclosed.