36098-33-6 Usage
Description
F16 is a cell-permeable mitochondrial toxin that possesses apoptotic and necrotic actions, specifically targeting tumor cell lines. Its ability to induce cell death in cancer cells makes it a potential candidate for various applications in the field of oncology.
Uses
Used in Anticancer Applications:
F16 is used as an anticancer agent for its apoptotic and necrotic effects on tumor cell lines. It targets cancer cells by disrupting mitochondrial function, leading to cell death and potentially offering a therapeutic approach for cancer treatment.
Used in Drug Delivery Systems:
In the pharmaceutical industry, F16 can be used as a component in the development of drug delivery systems. These systems can be designed to specifically target cancer cells, improving the bioavailability and therapeutic outcomes of F16 by ensuring its selective delivery to tumor sites while minimizing damage to healthy cells.
Biological Activity
f16 is a small, cationic, lipophilic, and fluorescent molecule capable of binding preferentially to mitochondrial membranes and disrupts their function. f16 is a potential antitumor agent.f16 affected growth in some mouse and human breast cancer cell lines. f16 resulted in a dramatic decrease in the number of cells in s phase and an increase in the percentage of cells in g1 phase [1]. prolonged incubation with 3 μm f16 led to increased cell death of f16-sensitive cells but not of f16-resistant ones. f16 accumulation in mitochondria induced mitochondrial damage characterized by imbalance of volumetric homeostasis, failure to synthesize atp, cytochrome c release and increased production of reactive oxy gen species [1]. f16 incubation decreased the cellular atp pool in both parental eph4-a6 and bcl-2-overexpressing eph4-a6.c13 and eph4-a6.c18 cells in a time-dependent manner [1]. treatment with f16 promoted early release of cytochrome c in transformed eph4-a6 cells. treatment with f16 (0.3-3 μm) resulted in the characteristic apoptotic dna laddering in the eph4-a6 cells. f16-induced mitochondrial dysfunction triggers apoptosis or necrosis. f16 induced necrosis in various cell lines resistant to apoptosis [2].
references
[1] fantin v r, berardi m j, scorrano l, et al. a novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth[j]. cancer cell, 2002, 2(1): 29-42.[2] fantin v r, leder p. f16, a mitochondriotoxic compound, triggers apoptosis or necrosis depending on the genetic background of the target carcinoma cell[j]. cancer research, 2004, 64(1): 329-336.
Check Digit Verification of cas no
The CAS Registry Mumber 36098-33-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,6,0,9 and 8 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 36098-33:
(7*3)+(6*6)+(5*0)+(4*9)+(3*8)+(2*3)+(1*3)=126
126 % 10 = 6
So 36098-33-6 is a valid CAS Registry Number.
36098-33-6Relevant articles and documents
Pyridinium and indole orientation determines the mitochondrial uncoupling and anti-cancer efficiency of F16
Xu, Juan,He, Huan,Zhou, Lian-Jiao,Liu, Yu-Zhu,Li, Dong-Wei,Jiang, Feng-Lei,Liu, Yi
, p. 305 - 313 (2018/05/30)
F16 is a mitochondria-targeted, broad-spectrum anticancer agent in the pre-clinic cancer therapy. Here we developed two fluorescent isomers of F16 (o-F16 and m-F16) with entirely different photophysical properties, uncoupling activity, and cytotoxicity by
Combinatorial approach to organelle-targeted fluorescent library based on the styryl scaffold
Rosania, Gustavo R.,Lee, Jae Wook,Ding, Liang,Yoon, Hai-Shin,Chang, Young-Tae
, p. 1130 - 1131 (2007/10/03)
The first fluorescent styryl dye library with a broad color range was synthesized by combinatorial condensation of various aldehydes and methyl pyridinium compounds, and their applications as organelle specific staining probes were demonstrated. Copyright
